DegronMD - Q7Z2K6(ERMP1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P130Q	TCGA-BF-A1PU	SKCM	TCGA	ARDYLEHIT	DEG_APCC_DBOX_1	112:120	Mutation rewiring degron network	0.0556
p.P130Q	DO50278	SKCM	ICGC	ARDYLEHIT	DEG_APCC_DBOX_1	112:120	Mutation rewiring degron network	0.0556
p.S102L	DO219016	BLCA	ICGC	ARDYLEHIT	DEG_APCC_DBOX_1	112:120	Mutation rewiring degron network	0.0556
p.R107H	DO234242	ESAD	ICGC	ARDYLEHIT	DEG_APCC_DBOX_1	112:120	Mutation rewiring degron network	0.1944
p.N114K	DO229038	LICA	ICGC	ARDYLEHIT	DEG_APCC_DBOX_1	112:120	Mutation altering degron motif	0.6918
p.H130N	DO229008	LICA	ICGC	ARDYLEHIT	DEG_APCC_DBOX_1	112:120	Mutation rewiring degron network	0.0556
p.D111N	DO26460	LUSC	ICGC	ARDYLEHIT	DEG_APCC_DBOX_1	112:120	Mutation rewiring degron network	0.3056
p.E124D	DO41488	UCEC	ICGC	ARDYLEHIT	DEG_APCC_DBOX_1	112:120	Mutation rewiring degron network	0.2222
p.T127P	ACH-002066	Sarcoma	CCLE	ARDYLEHIT	DEG_APCC_DBOX_1	112:120	Mutation rewiring degron network	0.1389

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons