DegronMD

Uniprot ID: Q7Z2K6

Source protein: Endoplasmic reticulum metallopeptidase 1

Source gene: ERMP1

Class: DEG_APCC_DBOX_1

Location: 112:120

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5632

ASA_SCORE: 38.4889

COIL: 0.0327

CONS_SCORE: 0.4444

DSS_SCORE: 0.2828

HELIX: 0.9663

FCONS_SCORE: 1.1493

RIG_SCORE: 0.8027

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P130Q	TCGA-BF-A1PU	SKCM	TCGA	ARDYLEHIT	DEG_APCC_DBOX_1	0.0556
p.P130Q	DO50278	SKCM	ICGC	ARDYLEHIT	DEG_APCC_DBOX_1	0.0556
p.S102L	DO219016	BLCA	ICGC	ARDYLEHIT	DEG_APCC_DBOX_1	0.0556
p.R107H	DO234242	ESAD	ICGC	ARDYLEHIT	DEG_APCC_DBOX_1	0.1944
p.N114K	DO229038	LICA	ICGC	ARDYLEHIT	DEG_APCC_DBOX_1	0.6918
p.H130N	DO229008	LICA	ICGC	ARDYLEHIT	DEG_APCC_DBOX_1	0.0556
p.D111N	DO26460	LUSC	ICGC	ARDYLEHIT	DEG_APCC_DBOX_1	0.3056
p.E124D	DO41488	UCEC	ICGC	ARDYLEHIT	DEG_APCC_DBOX_1	0.2222
p.T127P	ACH-002066	Sarcoma	CCLE	ARDYLEHIT	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z2K6	Endoplasmic reticulum metallopeptidase 1	DEG_APCC_DBOX_1	112:120	ARDYLEHIT	APC,CDC20,FZR1	0.5632	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons