DegronMD - Q7Z3B4(NUP54)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.W309C	TCGA-55-6979	LUAD	TCGA	NPPAGVDPI	DEG_SIAH_1	299:307	Mutation rewiring degron network	0.2778
p.W309C	DO24110	LUAD	ICGC	NPPAGVDPI	DEG_SIAH_1	299:307	Mutation rewiring degron network	0.2778
p.S289Y	TCGA-A5-A0G2	UCEC	TCGA	NPPAGVDPI	DEG_SIAH_1	299:307	Mutation blocking phosphorylation signal	0.5
p.S289Y	DO41235	UCEC	ICGC	NPPAGVDPI	DEG_SIAH_1	299:307	Mutation blocking phosphorylation signal	0.5
p.P290T	TCGA-CN-5360	HNSC	TCGA	NPPAGVDPI	DEG_SIAH_1	299:307	Mutation rewiring degron network	0.0833
p.P290T	DO14662	HNSC	ICGC	NPPAGVDPI	DEG_SIAH_1	299:307	Mutation rewiring degron network	0.0833
p.Q311K	DO229037	LICA	ICGC	NPPAGVDPI	DEG_SIAH_1	299:307	Mutation rewiring degron network	0.2222
p.Q311R	DO229264	THCA	ICGC	NPPAGVDPI	DEG_SIAH_1	299:307	Mutation rewiring degron network	0.2222
p.K313Q	SIDM01546	Kidney Carcinoma	GDSC	NPPAGVDPI	DEG_SIAH_1	299:307	Mutation blocking ubiquitination signal	0.6111

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons