DegronMD

Uniprot ID: Q7Z3B4

Source protein: Nucleoporin p54

Source gene: NUP54

Class: DEG_SIAH_1

Location: 299:307

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9773

ASA_SCORE: 63.8333

COIL: 0.7493

CONS_SCORE: 0.4543

DSS_SCORE: 0.3731

HELIX: 0.2342

FCONS_SCORE: 1.0071

RIG_SCORE: 0.7242

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W309C	TCGA-55-6979	LUAD	TCGA	NPPAGVDPI	DEG_SIAH_1	0.2778
p.W309C	DO24110	LUAD	ICGC	NPPAGVDPI	DEG_SIAH_1	0.2778
p.S289Y	TCGA-A5-A0G2	UCEC	TCGA	NPPAGVDPI	DEG_SIAH_1	0.5
p.S289Y	DO41235	UCEC	ICGC	NPPAGVDPI	DEG_SIAH_1	0.5
p.P290T	TCGA-CN-5360	HNSC	TCGA	NPPAGVDPI	DEG_SIAH_1	0.0833
p.P290T	DO14662	HNSC	ICGC	NPPAGVDPI	DEG_SIAH_1	0.0833
p.Q311K	DO229037	LICA	ICGC	NPPAGVDPI	DEG_SIAH_1	0.2222
p.Q311R	DO229264	THCA	ICGC	NPPAGVDPI	DEG_SIAH_1	0.2222
p.K313Q	SIDM01546	Kidney Carcinoma	GDSC	NPPAGVDPI	DEG_SIAH_1	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z3B4	Nucleoporin p54	DEG_SIAH_1	299:307	NPPAGVDPI	SIAH1,SIAH2,SIAH3	0.9773	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons