DegronMD - Q7Z3C6(ATG9A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R727W	TCGA-AX-A1CE	UCEC	TCGA	SDESGE	DEG_Kelch_Keap1_1	735:740	Mutation rewiring degron network	0.1111
p.A742T	TCGA-AZ-6598	COAD	TCGA	SDESGE	DEG_Kelch_Keap1_1	735:740	Mutation rewiring degron network	0.2778
p.R733W	TCGA-EI-6507	READ	TCGA	SDESGE	DEG_Kelch_Keap1_1	735:740	Mutation rewiring degron network	0.2778
p.V736A	DO48391	BLCA	ICGC	SDESGE	DEG_Kelch_Keap1_1	735:740	Mutation altering degron motif	0.6936
p.S738C	DO481	BLCA	ICGC	SDESGE	DEG_Kelch_Keap1_1	735:740	Mutation altering degron motif	0.8652
p.R742Q	DO14990	HNSC	ICGC	SDESGE	DEG_Kelch_Keap1_1	735:740	Mutation rewiring degron network	0.2778
p.T728K	DO229015	LICA	ICGC	SDESGE	DEG_Kelch_Keap1_1	735:740	Mutation rewiring degron network	0.1389
p.G725S	DO229052	LICA	ICGC	SDESGE	DEG_Kelch_Keap1_1	735:740	Mutation rewiring degron network	0.0556
p.F740L	DO36556	READ	ICGC	SDESGE	DEG_Kelch_Keap1_1	735:740	Mutation altering degron motif	0.6981
p.R735S	DO36491	READ	ICGC	SDESGE	DEG_Kelch_Keap1_1	735:740	Mutation altering degron motif	0.7427
p.G731C	DO229227	THCA	ICGC	SDESGE	DEG_Kelch_Keap1_1	735:740	Mutation rewiring degron network	0.2222
p.G731S	DO229234	THCA	ICGC	SDESGE	DEG_Kelch_Keap1_1	735:740	Mutation rewiring degron network	0.2222
p.G747W	DO42472	UCEC	ICGC	SDESGE	DEG_Kelch_Keap1_1	735:740	Mutation rewiring degron network	0.1389
p.R732H	SIDM00820	Kidney Carcinoma	GDSC	SDESGE	DEG_Kelch_Keap1_1	735:740	Mutation rewiring degron network	0.25

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons