DegronMD

Uniprot ID: Q7Z3C6

Source protein: Autophagy-related protein 9A

Source gene: ATG9A

Class: DEG_Kelch_Keap1_1

Location: 735:740

E3 ligase: KEAP1

DEGRON score: 0.9653

ASA_SCORE: 97.6667

COIL: 0.9282

CONS_SCORE: 0.2369

DSS_SCORE: 0.7424

HELIX: 0.0612

FCONS_SCORE: 0.9595

RIG_SCORE: 0.5369

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R727W	TCGA-AX-A1CE	UCEC	TCGA	SDESGE	DEG_Kelch_Keap1_1	0.1111
p.A742T	TCGA-AZ-6598	COAD	TCGA	SDESGE	DEG_Kelch_Keap1_1	0.2778
p.R733W	TCGA-EI-6507	READ	TCGA	SDESGE	DEG_Kelch_Keap1_1	0.2778
p.V736A	DO48391	BLCA	ICGC	SDESGE	DEG_Kelch_Keap1_1	0.6936
p.S738C	DO481	BLCA	ICGC	SDESGE	DEG_Kelch_Keap1_1	0.8652
p.R742Q	DO14990	HNSC	ICGC	SDESGE	DEG_Kelch_Keap1_1	0.2778
p.T728K	DO229015	LICA	ICGC	SDESGE	DEG_Kelch_Keap1_1	0.1389
p.G725S	DO229052	LICA	ICGC	SDESGE	DEG_Kelch_Keap1_1	0.0556
p.F740L	DO36556	READ	ICGC	SDESGE	DEG_Kelch_Keap1_1	0.6981
p.R735S	DO36491	READ	ICGC	SDESGE	DEG_Kelch_Keap1_1	0.7427
p.G731C	DO229227	THCA	ICGC	SDESGE	DEG_Kelch_Keap1_1	0.2222
p.G731S	DO229234	THCA	ICGC	SDESGE	DEG_Kelch_Keap1_1	0.2222
p.G747W	DO42472	UCEC	ICGC	SDESGE	DEG_Kelch_Keap1_1	0.1389
p.R732H	SIDM00820	Kidney Carcinoma	GDSC	SDESGE	DEG_Kelch_Keap1_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons