DegronMD

Uniprot ID: Q6PKG0

Source protein: La-related protein 1

Source gene: LARP1

Class: DEG_Kelch_Keap1_1

Location: 225:230

E3 ligase: KEAP1

DEGRON score: 0.9811

ASA_SCORE: 84.8333

COIL: 0.8718

CONS_SCORE: 0.3176

DSS_SCORE: 0.7194

HELIX: 0.1045

FCONS_SCORE: 1.0426

RIG_SCORE: 0.5304

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V222M	TCGA-E6-A1LX	UCEC	TCGA	SDESGE	DEG_Kelch_Keap1_1	0.3611
p.V222M	DO41020	UCEC	ICGC	SDESGE	DEG_Kelch_Keap1_1	0.3611
p.V222M	SIDM00487	Colorectal Carcinoma	GDSC	SDESGE	DEG_Kelch_Keap1_1	0.3611
p.V220M	TCGA-VQ-A8P2	STAD	TCGA	SDESGE	DEG_Kelch_Keap1_1	0.6389
p.V220M	DO51761	STAD	ICGC	SDESGE	DEG_Kelch_Keap1_1	0.6389
p.S216C	DO222603	BTCA	ICGC	SDESGE	DEG_Kelch_Keap1_1	0.0833
p.I233T	SIDM00845	Burkitt's Lymphoma	GDSC	SDESGE	DEG_Kelch_Keap1_1	0.25
p.P235A	SIDM00845	Burkitt's Lymphoma	GDSC	SDESGE	DEG_Kelch_Keap1_1	0.1944
p.P235L	SIDM00845	Burkitt's Lymphoma	GDSC	SDESGE	DEG_Kelch_Keap1_1	0.1944
p.A223G	SIDM01113	Other Sarcomas	GDSC	SDESGE	DEG_Kelch_Keap1_1	0.7222
p.V222L	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	SDESGE	DEG_Kelch_Keap1_1	0.3611
p.V222L	ACH-000929	Lung Cancer	CCLE	SDESGE	DEG_Kelch_Keap1_1	0.3611
p.V222L	NCI-H2110	lung	COSMIC	SDESGE	DEG_Kelch_Keap1_1	0.3611
p.A217V	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	SDESGE	DEG_Kelch_Keap1_1	0.5556
p.A217V	ACH-000951	Lung Cancer	CCLE	SDESGE	DEG_Kelch_Keap1_1	0.5556
p.A217V	NCI-H2342	lung	COSMIC	SDESGE	DEG_Kelch_Keap1_1	0.5556
p.T226P	LS-513	large_intestine	COSMIC	SDESGE	DEG_Kelch_Keap1_1	0.7031

DegronMD: protein-targeted degradation, mutation and drug response to degrons