DegronMD - Q7Z3D4(LYSMD3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q192H	TCGA-22-1000	LUSC	TCGA	KRENLNEVV	DEG_APCC_DBOX_1	178:186	Mutation rewiring degron network	0.1667
p.Q192H	DO27060	LUSC	ICGC	KRENLNEVV	DEG_APCC_DBOX_1	178:186	Mutation rewiring degron network	0.1667
p.S187L	TCGA-2J-AABT	PAAD	TCGA	KRENLNEVV	DEG_APCC_DBOX_1	178:186	Mutation rewiring degron network	0.3056
p.S187L	DO222595	MELA	ICGC	KRENLNEVV	DEG_APCC_DBOX_1	178:186	Mutation rewiring degron network	0.3056
p.S187L	DO51670	PAAD	ICGC	KRENLNEVV	DEG_APCC_DBOX_1	178:186	Mutation rewiring degron network	0.3056
p.V186L	TCGA-BA-A4II	HNSC	TCGA	KRENLNEVV	DEG_APCC_DBOX_1	178:186	Mutation altering degron motif	0.5654
p.V186L	DO52030	HNSC	ICGC	KRENLNEVV	DEG_APCC_DBOX_1	178:186	Mutation altering degron motif	0.5654
p.T175A	TCGA-BS-A0UV	UCEC	TCGA	KRENLNEVV	DEG_APCC_DBOX_1	178:186	Mutation rewiring degron network	0.25
p.T175A	DO42793	UCEC	ICGC	KRENLNEVV	DEG_APCC_DBOX_1	178:186	Mutation rewiring degron network	0.25
p.E180D	TCGA-EE-A3AD	SKCM	TCGA	KRENLNEVV	DEG_APCC_DBOX_1	178:186	Mutation altering degron motif	0.5647
p.E180D	DO37707	SKCM	ICGC	KRENLNEVV	DEG_APCC_DBOX_1	178:186	Mutation altering degron motif	0.5647
p.T190R	SIDM00582	Pancreatic Carcinoma	GDSC	KRENLNEVV	DEG_APCC_DBOX_1	178:186	Mutation rewiring degron network	0.2222
p.T190R	ACH-000281	Pancreatic Cancer	CCLE	KRENLNEVV	DEG_APCC_DBOX_1	178:186	Mutation rewiring degron network	0.2222
p.T190R	KP-2	pancreas	COSMIC	KRENLNEVV	DEG_APCC_DBOX_1	178:186	Mutation rewiring degron network	0.2222
p.M194L	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	KRENLNEVV	DEG_APCC_DBOX_1	178:186	Mutation rewiring degron network	0.1111
p.M194L	SIDM00032	Bladder Carcinoma	GDSC	KRENLNEVV	DEG_APCC_DBOX_1	178:186	Mutation rewiring degron network	0.1111
p.M194L	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	KRENLNEVV	DEG_APCC_DBOX_1	178:186	Mutation rewiring degron network	0.1111
p.M194L	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	KRENLNEVV	DEG_APCC_DBOX_1	178:186	Mutation rewiring degron network	0.1111
p.M194L	SIDM00808	Burkitt's Lymphoma	GDSC	KRENLNEVV	DEG_APCC_DBOX_1	178:186	Mutation rewiring degron network	0.1111
p.M194L	SIDM01254	Burkitt's Lymphoma	GDSC	KRENLNEVV	DEG_APCC_DBOX_1	178:186	Mutation rewiring degron network	0.1111

Kaplan plot for LYSMD3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LYSMD3

UniProt ID: Q7Z3D4

Entrez ID: 116068

Protein name: LysM and putative peptidoglycan-binding domain-containing protein 3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LYSMD3 in