DegronMD

Uniprot ID: Q7Z3D4

Source protein: LysM and putative peptidoglycan-binding domain-containing protein 3

Source gene: LYSMD3

Class: DEG_APCC_DBOX_1

Location: 178:186

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5966

ASA_SCORE: 93.8889

COIL: 0.3841

CONS_SCORE: 0.4823

DSS_SCORE: 0.3646

HELIX: 0.592

FCONS_SCORE: 1.097

RIG_SCORE: 0.791

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q192H	TCGA-22-1000	LUSC	TCGA	KRENLNEVV	DEG_APCC_DBOX_1	0.1667
p.Q192H	DO27060	LUSC	ICGC	KRENLNEVV	DEG_APCC_DBOX_1	0.1667
p.S187L	TCGA-2J-AABT	PAAD	TCGA	KRENLNEVV	DEG_APCC_DBOX_1	0.3056
p.S187L	DO222595	MELA	ICGC	KRENLNEVV	DEG_APCC_DBOX_1	0.3056
p.S187L	DO51670	PAAD	ICGC	KRENLNEVV	DEG_APCC_DBOX_1	0.3056
p.V186L	TCGA-BA-A4II	HNSC	TCGA	KRENLNEVV	DEG_APCC_DBOX_1	0.5654
p.V186L	DO52030	HNSC	ICGC	KRENLNEVV	DEG_APCC_DBOX_1	0.5654
p.T175A	TCGA-BS-A0UV	UCEC	TCGA	KRENLNEVV	DEG_APCC_DBOX_1	0.25
p.T175A	DO42793	UCEC	ICGC	KRENLNEVV	DEG_APCC_DBOX_1	0.25
p.E180D	TCGA-EE-A3AD	SKCM	TCGA	KRENLNEVV	DEG_APCC_DBOX_1	0.5647
p.E180D	DO37707	SKCM	ICGC	KRENLNEVV	DEG_APCC_DBOX_1	0.5647
p.T190R	SIDM00582	Pancreatic Carcinoma	GDSC	KRENLNEVV	DEG_APCC_DBOX_1	0.2222
p.T190R	ACH-000281	Pancreatic Cancer	CCLE	KRENLNEVV	DEG_APCC_DBOX_1	0.2222
p.T190R	KP-2	pancreas	COSMIC	KRENLNEVV	DEG_APCC_DBOX_1	0.2222
p.M194L	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	KRENLNEVV	DEG_APCC_DBOX_1	0.1111
p.M194L	SIDM00032	Bladder Carcinoma	GDSC	KRENLNEVV	DEG_APCC_DBOX_1	0.1111
p.M194L	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	KRENLNEVV	DEG_APCC_DBOX_1	0.1111
p.M194L	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	KRENLNEVV	DEG_APCC_DBOX_1	0.1111
p.M194L	SIDM00808	Burkitt's Lymphoma	GDSC	KRENLNEVV	DEG_APCC_DBOX_1	0.1111
p.M194L	SIDM01254	Burkitt's Lymphoma	GDSC	KRENLNEVV	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z3D4	LysM and putative peptidoglycan-binding domain-containing protein 3	DEG_APCC_DBOX_1	178:186	KRENLNEVV	APC,CDC20,FZR1	0.5966	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons