DegronMD - Q7Z3E1(TIPARP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E31G	TCGA-56-8504	LUSC	TCGA	ITPLKT	DEG_SCF_FBW7_1	33:38	Mutation rewiring degron network	0.2778
p.E31G	DO45437	LUSC	ICGC	ITPLKT	DEG_SCF_FBW7_1	33:38	Mutation rewiring degron network	0.2778
p.K43N	TCGA-AX-A2HC	UCEC	TCGA	ITPLKT	DEG_SCF_FBW7_1	33:38	Mutation substituting flanking lysine	0.3056
p.K43N	DO41572	UCEC	ICGC	ITPLKT	DEG_SCF_FBW7_1	33:38	Mutation substituting flanking lysine	0.3056
p.R47K	TCGA-D7-5577	STAD	TCGA	ITPLKT	DEG_SCF_FBW7_1	33:38	Mutation rewiring degron network	0.0833
p.R47K	DO38631	STAD	ICGC	ITPLKT	DEG_SCF_FBW7_1	33:38	Mutation rewiring degron network	0.0833
p.P35L	TCGA-EB-A85J	SKCM	TCGA	ITPLKT	DEG_SCF_FBW7_1	33:38	Mutation altering degron motif	0.7582
p.P35L	DO50297	SKCM	ICGC	ITPLKT	DEG_SCF_FBW7_1	33:38	Mutation altering degron motif	0.7582
p.P35S	TCGA-ER-A42L	SKCM	TCGA	ITPLKT	DEG_SCF_FBW7_1	33:38	Mutation altering degron motif	0.6752
p.P35S	DO223910	SKCM	ICGC	ITPLKT	DEG_SCF_FBW7_1	33:38	Mutation altering degron motif	0.6752
p.I33V	DO222895	BTCA	ICGC	ITPLKT	DEG_SCF_FBW7_1	33:38	Mutation altering degron motif	0.5965
p.K46T	DO228893	LICA	ICGC	ITPLKT	DEG_SCF_FBW7_1	33:38	Mutation substituting flanking lysine	0.2222
p.F23L	SIDM00878	Breast Carcinoma	GDSC	ITPLKT	DEG_SCF_FBW7_1	33:38	Mutation rewiring degron network	0.0556
p.F23L	ACH-000930	Breast Cancer	CCLE	ITPLKT	DEG_SCF_FBW7_1	33:38	Mutation rewiring degron network	0.0556
p.F23L	HCC1569	breast	COSMIC	ITPLKT	DEG_SCF_FBW7_1	33:38	Mutation rewiring degron network	0.0556
p.R47I	SIDM01611	Endometrial Carcinoma	GDSC	ITPLKT	DEG_SCF_FBW7_1	33:38	Mutation rewiring degron network	0.0833
p.R47I	ACH-000996	Endometrial/Uterine Cancer	CCLE	ITPLKT	DEG_SCF_FBW7_1	33:38	Mutation rewiring degron network	0.0833

Kaplan plot for TIPARP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TIPARP

UniProt ID: Q7Z3E1

Entrez ID: 25976

Protein name: Protein mono-ADP-ribosyltransferase TIPARP (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 14) (ARTD14) (Poly [ADP-ribose] polymerase 7) (PARP-7) (TCDD-inducible poly [ADP-ribose] polymerase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TIPARP in