DegronMD

Uniprot ID: Q7Z3E1

Source protein: Protein mono-ADP-ribosyltransferase TIPARP

Source gene: TIPARP

Class: DEG_SCF_FBW7_1

Location: 33:38

E3 ligase: FBXW7

DEGRON score: 0.9685

ASA_SCORE: 60.3667

COIL: 0.7605

CONS_SCORE: 0.7823

DSS_SCORE: 0.4012

HELIX: 0.0952

FCONS_SCORE: 1.0906

RIG_SCORE: 0.8011

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E31G	TCGA-56-8504	LUSC	TCGA	ITPLKT	DEG_SCF_FBW7_1	0.2778
p.E31G	DO45437	LUSC	ICGC	ITPLKT	DEG_SCF_FBW7_1	0.2778
p.K43N	TCGA-AX-A2HC	UCEC	TCGA	ITPLKT	DEG_SCF_FBW7_1	0.3056
p.K43N	DO41572	UCEC	ICGC	ITPLKT	DEG_SCF_FBW7_1	0.3056
p.R47K	TCGA-D7-5577	STAD	TCGA	ITPLKT	DEG_SCF_FBW7_1	0.0833
p.R47K	DO38631	STAD	ICGC	ITPLKT	DEG_SCF_FBW7_1	0.0833
p.P35L	TCGA-EB-A85J	SKCM	TCGA	ITPLKT	DEG_SCF_FBW7_1	0.7582
p.P35L	DO50297	SKCM	ICGC	ITPLKT	DEG_SCF_FBW7_1	0.7582
p.P35S	TCGA-ER-A42L	SKCM	TCGA	ITPLKT	DEG_SCF_FBW7_1	0.6752
p.P35S	DO223910	SKCM	ICGC	ITPLKT	DEG_SCF_FBW7_1	0.6752
p.I33V	DO222895	BTCA	ICGC	ITPLKT	DEG_SCF_FBW7_1	0.5965
p.K46T	DO228893	LICA	ICGC	ITPLKT	DEG_SCF_FBW7_1	0.2222
p.F23L	SIDM00878	Breast Carcinoma	GDSC	ITPLKT	DEG_SCF_FBW7_1	0.0556
p.F23L	ACH-000930	Breast Cancer	CCLE	ITPLKT	DEG_SCF_FBW7_1	0.0556
p.F23L	HCC1569	breast	COSMIC	ITPLKT	DEG_SCF_FBW7_1	0.0556
p.R47I	SIDM01611	Endometrial Carcinoma	GDSC	ITPLKT	DEG_SCF_FBW7_1	0.0833
p.R47I	ACH-000996	Endometrial/Uterine Cancer	CCLE	ITPLKT	DEG_SCF_FBW7_1	0.0833

Drug responses associated with TIPARP mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM01031	ESCA\|oesophagus	p.E7K (No)	GDSC	PARP_9495	25.7443
SIDM00499	PRAD\|prostate	p.Y320H (No)	GDSC	PARP_9495	36.9307
SIDM01036	MM\|haematopoietic_neoplasm_other	p.S580F (No)	GDSC	PARP_9495	6.5918
SIDM00145	ALL\|lymphoblastic_leukemia	p.G594D (No)	GDSC	PARP_9495	1.0511
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.T150M (No)	GDSC	PARP_9495	2.407
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.V319M (No)	GDSC	PARP_9495	2.407
SIDM00584	UNCLASSIFIED\|osteosarcoma	p.D21G (No)	GDSC	PARP_9495	5.744
SIDM01048	MM\|lymphoid_neoplasm_other	p.D81N (No)	GDSC	PARP_9495	18.2269
SIDM01048	MM\|lymphoid_neoplasm_other	p.E82Q (No)	GDSC	PARP_9495	18.2269
SIDM00719	SCLC\|lung_small_cell_carcinoma	p.H573L (No)	GDSC	PARP_9495	46.303
SIDM00762	LUAD\|lung_NSCLC_adenocarcinoma	p.R330S (No)	GDSC	PARP_9495	1.5619
SIDM00142	UCEC\|endometrium	p.R329* (No)	GDSC	PARP_9495	25.9033
SIDM01009	NB\|neuroblastoma	p.E487D (No)	GDSC	PARP_9495	3.8477
SIDM00251	STAD\|stomach	p.L258S (No)	GDSC	PARP_9495	6.1931
SIDM00303	OV\|ovary	p.T128P (No)	GDSC	PARP_9495	14.9669
SIDM00217	COREAD\|large_intestine	p.G239E (No)	GDSC	PARP_9495	28.4059
SIDM00217	COREAD\|large_intestine	p.R374Q (No)	GDSC	PARP_9495	28.4059
SIDM00217	COREAD\|large_intestine	p.R523G (No)	GDSC	PARP_9495	28.4059
SIDM00889	CESC\|cervix	p.T262N (No)	GDSC	PARP_9495	1.5315
SIDM00898	BRCA\|breast	p.M303I (No)	GDSC	PARP_9495	0.9454
SIDM00955	SKCM\|melanoma	p.P175L (No)	GDSC	PARP_9495	34.2208
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.E65D (No)	GDSC	PARP_9495	29.2395
SIDM00501	HNSC\|head_and_neck	p.N372T (No)	GDSC	PARP_9495	8.2305
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L618F (No)	GDSC	PARP_9495	3.9442
SIDM00101	MESO\|mesothelioma	p.N372T (No)	GDSC	PARP_9495	26.6216
SIDM00330	NB\|neuroblastoma	p.P426T (No)	GDSC	PARP_9495	27.602
SIDM00744	LUAD\|lung_NSCLC_adenocarcinoma	p.D540N (No)	GDSC	PARP_9495	1.761
SIDM01178	UNCLASSIFIED\|urogenital_system_other	p.D204N (No)	GDSC	PARP_9495	0.9624
SIDM00878	BRCA\|breast	p.F23L (Yes)	GDSC	PARP_9495	6.0142
SIDM00118	COREAD\|large_intestine	p.E7K (No)	GDSC	PARP_9495	3.1972

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ITPLKT

Degron related mutations and impact score

Drug responses associated with TIPARP mutations

All proteins holding degron of ITPLKT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z3E1	Protein mono-ADP-ribosyltransferase TIPARP	DEG_SCF_FBW7_1	33:38	ITPLKT	FBXW7	0.9685	More...