DegronMD - Q7Z3E5(ARMC9)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R652S	TCGA-04-1357	OV	TCGA	RRKGLANVQ	DEG_APCC_DBOX_1	635:643	Mutation rewiring degron network	0.0833
p.R652S	DO27980	OV	ICGC	RRKGLANVQ	DEG_APCC_DBOX_1	635:643	Mutation rewiring degron network	0.0833
p.G646W	TCGA-AA-A02R	COAD	TCGA	RRKGLANVQ	DEG_APCC_DBOX_1	635:643	Mutation rewiring degron network	0.25
p.L639M	TCGA-AP-A051	UCEC	TCGA	RRKGLANVQ	DEG_APCC_DBOX_1	635:643	Mutation altering degron motif	0.711
p.L639M	DO42673	UCEC	ICGC	RRKGLANVQ	DEG_APCC_DBOX_1	635:643	Mutation altering degron motif	0.711
p.L650Q	TCGA-CV-7434	HNSC	TCGA	RRKGLANVQ	DEG_APCC_DBOX_1	635:643	Mutation rewiring degron network	0.1389
p.L650Q	DO15831	HNSC	ICGC	RRKGLANVQ	DEG_APCC_DBOX_1	635:643	Mutation rewiring degron network	0.1389
p.E719K	SIDM01175	Other Sarcomas	GDSC	VSSSS	DEG_SPOP_SBC_1	707:711	Mutation rewiring degron network	0.1111
p.A715T	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	707:711	Mutation rewiring degron network	0.2222
p.A715T	RERF-LC-KJ	lung	COSMIC	VSSSS	DEG_SPOP_SBC_1	707:711	Mutation rewiring degron network	0.2222
p.T631M	SIDM00943	Pancreatic Carcinoma	GDSC	RRKGLANVQ	DEG_APCC_DBOX_1	635:643	Mutation rewiring degron network	0.2222
p.T631M	ACH-000107	Pancreatic Cancer	CCLE	RRKGLANVQ	DEG_APCC_DBOX_1	635:643	Mutation rewiring degron network	0.2222
p.T631M	Capan-2	pancreas	COSMIC	RRKGLANVQ	DEG_APCC_DBOX_1	635:643	Mutation rewiring degron network	0.2222
p.N630S	SIDM00217	Colorectal Carcinoma	GDSC	RRKGLANVQ	DEG_APCC_DBOX_1	635:643	Mutation rewiring degron network	0.1944
p.N630S	ACH-000999	Colon/Colorectal Cancer	CCLE	RRKGLANVQ	DEG_APCC_DBOX_1	635:643	Mutation rewiring degron network	0.1944
p.N630S	SNU-1040	large intestine	COSMIC	RRKGLANVQ	DEG_APCC_DBOX_1	635:643	Mutation rewiring degron network	0.1944
p.A640V	SIDM00217	Colorectal Carcinoma	GDSC	RRKGLANVQ	DEG_APCC_DBOX_1	635:643	Mutation altering degron motif	0.5825
p.A640V	ACH-000999	Colon/Colorectal Cancer	CCLE	RRKGLANVQ	DEG_APCC_DBOX_1	635:643	Mutation altering degron motif	0.5825
p.A640V	SNU-1040	large intestine	COSMIC	RRKGLANVQ	DEG_APCC_DBOX_1	635:643	Mutation altering degron motif	0.5825
p.T629I	SIDM00079	Ovarian Carcinoma	GDSC	RRKGLANVQ	DEG_APCC_DBOX_1	635:643	Mutation rewiring degron network	0.1667
p.T629I	ACH-000811	Ovarian Cancer	CCLE	RRKGLANVQ	DEG_APCC_DBOX_1	635:643	Mutation rewiring degron network	0.1667
p.T629I	SK-OV-3	ovary	COSMIC	RRKGLANVQ	DEG_APCC_DBOX_1	635:643	Mutation rewiring degron network	0.1667

Kaplan plot for ARMC9 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARMC9

UniProt ID: Q7Z3E5

Entrez ID: 80210

Protein name: LisH domain-containing protein ARMC9 (Armadillo repeat-containing protein 9) (Melanoma/melanocyte-specific tumor antigen KU-MEL-1) (NS21)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ARMC9 in