DegronMD

Uniprot ID: Q7Z3E5

Source protein: LisH domain-containing protein ARMC9

Source gene: ARMC9

Class: DEG_APCC_DBOX_1

Location: 635:643

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7946

ASA_SCORE: 105.9889

COIL: 0.8509

CONS_SCORE: 0.3013

DSS_SCORE: 0.5347

HELIX: 0.079

FCONS_SCORE: 0.7589

RIG_SCORE: 0.7582

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R652S	TCGA-04-1357	OV	TCGA	RRKGLANVQ	DEG_APCC_DBOX_1	0.0833
p.R652S	DO27980	OV	ICGC	RRKGLANVQ	DEG_APCC_DBOX_1	0.0833
p.G646W	TCGA-AA-A02R	COAD	TCGA	RRKGLANVQ	DEG_APCC_DBOX_1	0.25
p.L639M	TCGA-AP-A051	UCEC	TCGA	RRKGLANVQ	DEG_APCC_DBOX_1	0.711
p.L639M	DO42673	UCEC	ICGC	RRKGLANVQ	DEG_APCC_DBOX_1	0.711
p.L650Q	TCGA-CV-7434	HNSC	TCGA	RRKGLANVQ	DEG_APCC_DBOX_1	0.1389
p.L650Q	DO15831	HNSC	ICGC	RRKGLANVQ	DEG_APCC_DBOX_1	0.1389
p.T631M	SIDM00943	Pancreatic Carcinoma	GDSC	RRKGLANVQ	DEG_APCC_DBOX_1	0.2222
p.T631M	ACH-000107	Pancreatic Cancer	CCLE	RRKGLANVQ	DEG_APCC_DBOX_1	0.2222
p.T631M	Capan-2	pancreas	COSMIC	RRKGLANVQ	DEG_APCC_DBOX_1	0.2222
p.N630S	SIDM00217	Colorectal Carcinoma	GDSC	RRKGLANVQ	DEG_APCC_DBOX_1	0.1944
p.N630S	ACH-000999	Colon/Colorectal Cancer	CCLE	RRKGLANVQ	DEG_APCC_DBOX_1	0.1944
p.N630S	SNU-1040	large_intestine	COSMIC	RRKGLANVQ	DEG_APCC_DBOX_1	0.1944
p.A640V	SIDM00217	Colorectal Carcinoma	GDSC	RRKGLANVQ	DEG_APCC_DBOX_1	0.5825
p.A640V	ACH-000999	Colon/Colorectal Cancer	CCLE	RRKGLANVQ	DEG_APCC_DBOX_1	0.5825
p.A640V	SNU-1040	large_intestine	COSMIC	RRKGLANVQ	DEG_APCC_DBOX_1	0.5825
p.T629I	SIDM00079	Ovarian Carcinoma	GDSC	RRKGLANVQ	DEG_APCC_DBOX_1	0.1667
p.T629I	ACH-000811	Ovarian Cancer	CCLE	RRKGLANVQ	DEG_APCC_DBOX_1	0.1667
p.T629I	SK-OV-3	ovary	COSMIC	RRKGLANVQ	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z3E5	LisH domain-containing protein ARMC9	DEG_APCC_DBOX_1	635:643	RRKGLANVQ	APC,CDC20,FZR1	0.7946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons