DegronMD - Q7Z3H4(SAMD7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L150Q	TCGA-17-Z062	LUAD	TCGA	HRSTLRNLQ	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.25
p.A147D	TCGA-43-2581	LUSC	TCGA	HRSTLRNLQ	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.1667
p.A147D	DO26602	LUSC	ICGC	HRSTLRNLQ	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.1667
p.L145I	TCGA-A5-A0G2	UCEC	TCGA	HRSTLRNLQ	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.1111
p.L145I	DO41235	UCEC	ICGC	HRSTLRNLQ	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.1111
p.L157F	TCGA-A6-6781	COAD	TCGA	HRSTLRNLQ	DEG_APCC_DBOX_1	153:161	Mutation altering degron motif	0.6981
p.L157F	DO8447	COAD	ICGC	HRSTLRNLQ	DEG_APCC_DBOX_1	153:161	Mutation altering degron motif	0.6981
p.P146H	TCGA-EE-A29E	SKCM	TCGA	HRSTLRNLQ	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.1389
p.P146H	DO37831	SKCM	ICGC	HRSTLRNLQ	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.1389
p.P171S	TCGA-EY-A1GC	UCEC	TCGA	HRSTLRNLQ	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.0556
p.P171S	DO41068	UCEC	ICGC	HRSTLRNLQ	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.0556
p.L150P	TCGA-LB-A8F3	PAAD	TCGA	HRSTLRNLQ	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.25
p.L150P	DO50262	PAAD	ICGC	HRSTLRNLQ	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.25
p.P146L	TCGA-P3-A5Q5	HNSC	TCGA	HRSTLRNLQ	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.1389
p.P146L	DO44450	HNSC	ICGC	HRSTLRNLQ	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.1389
p.G162R	TCGA-QC-A7B5	SARC	TCGA	HRSTLRNLQ	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.3056
p.G162R	DO220239	SARC	ICGC	HRSTLRNLQ	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.3056
p.G162E	DO224594	LUSC	ICGC	HRSTLRNLQ	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.3056
p.P146S	DO220887	MELA	ICGC	HRSTLRNLQ	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.1389
p.Q161L	DO231315	THCA	ICGC	HRSTLRNLQ	DEG_APCC_DBOX_1	153:161	Mutation altering degron motif	0.6654
p.R158T	SIDM00399	Head and Neck Carcinoma	GDSC	HRSTLRNLQ	DEG_APCC_DBOX_1	153:161	Mutation altering degron motif	0.6765
p.R158T	ACH-001228		CCLE	HRSTLRNLQ	DEG_APCC_DBOX_1	153:161	Mutation altering degron motif	0.6765
p.R158T	SCC90	upper aerodigestive tract	COSMIC	HRSTLRNLQ	DEG_APCC_DBOX_1	153:161	Mutation altering degron motif	0.6765
p.N163Y	SIDM00003	Melanoma	GDSC	HRSTLRNLQ	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.2778
p.N163Y	ACH-000884	Skin Cancer	CCLE	HRSTLRNLQ	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.2778
p.N163Y	ACH-002159	Skin Cancer	CCLE	HRSTLRNLQ	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.2778
p.N163Y	M14	skin	COSMIC	HRSTLRNLQ	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.2778

Kaplan plot for SAMD7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SAMD7

UniProt ID: Q7Z3H4

Entrez ID: 344658

Protein name: Sterile alpha motif domain-containing protein 7 (SAM domain-containing protein 7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SAMD7 in