DegronMD

Uniprot ID: Q7Z3H4

Source protein: Sterile alpha motif domain-containing protein 7

Source gene: SAMD7

Class: DEG_APCC_DBOX_1

Location: 153:161

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7515

ASA_SCORE: 81.7444

COIL: 0.6178

CONS_SCORE: 0.6969

DSS_SCORE: 0.4085

HELIX: 0.2816

FCONS_SCORE: 1.0689

RIG_SCORE: 0.7398

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L150Q	TCGA-17-Z062	LUAD	TCGA	HRSTLRNLQ	DEG_APCC_DBOX_1	0.25
p.A147D	TCGA-43-2581	LUSC	TCGA	HRSTLRNLQ	DEG_APCC_DBOX_1	0.1667
p.A147D	DO26602	LUSC	ICGC	HRSTLRNLQ	DEG_APCC_DBOX_1	0.1667
p.L145I	TCGA-A5-A0G2	UCEC	TCGA	HRSTLRNLQ	DEG_APCC_DBOX_1	0.1111
p.L145I	DO41235	UCEC	ICGC	HRSTLRNLQ	DEG_APCC_DBOX_1	0.1111
p.L157F	TCGA-A6-6781	COAD	TCGA	HRSTLRNLQ	DEG_APCC_DBOX_1	0.6981
p.L157F	DO8447	COAD	ICGC	HRSTLRNLQ	DEG_APCC_DBOX_1	0.6981
p.P146H	TCGA-EE-A29E	SKCM	TCGA	HRSTLRNLQ	DEG_APCC_DBOX_1	0.1389
p.P146H	DO37831	SKCM	ICGC	HRSTLRNLQ	DEG_APCC_DBOX_1	0.1389
p.P171S	TCGA-EY-A1GC	UCEC	TCGA	HRSTLRNLQ	DEG_APCC_DBOX_1	0.0556
p.P171S	DO41068	UCEC	ICGC	HRSTLRNLQ	DEG_APCC_DBOX_1	0.0556
p.L150P	TCGA-LB-A8F3	PAAD	TCGA	HRSTLRNLQ	DEG_APCC_DBOX_1	0.25
p.L150P	DO50262	PAAD	ICGC	HRSTLRNLQ	DEG_APCC_DBOX_1	0.25
p.P146L	TCGA-P3-A5Q5	HNSC	TCGA	HRSTLRNLQ	DEG_APCC_DBOX_1	0.1389
p.P146L	DO44450	HNSC	ICGC	HRSTLRNLQ	DEG_APCC_DBOX_1	0.1389
p.G162R	TCGA-QC-A7B5	SARC	TCGA	HRSTLRNLQ	DEG_APCC_DBOX_1	0.3056
p.G162R	DO220239	SARC	ICGC	HRSTLRNLQ	DEG_APCC_DBOX_1	0.3056
p.G162E	DO224594	LUSC	ICGC	HRSTLRNLQ	DEG_APCC_DBOX_1	0.3056
p.P146S	DO220887	MELA	ICGC	HRSTLRNLQ	DEG_APCC_DBOX_1	0.1389
p.Q161L	DO231315	THCA	ICGC	HRSTLRNLQ	DEG_APCC_DBOX_1	0.6654
p.R158T	SIDM00399	Head and Neck Carcinoma	GDSC	HRSTLRNLQ	DEG_APCC_DBOX_1	0.6765
p.R158T	ACH-001228		CCLE	HRSTLRNLQ	DEG_APCC_DBOX_1	0.6765
p.R158T	SCC90	upper_aerodigestive_tract	COSMIC	HRSTLRNLQ	DEG_APCC_DBOX_1	0.6765
p.N163Y	SIDM00003	Melanoma	GDSC	HRSTLRNLQ	DEG_APCC_DBOX_1	0.2778
p.N163Y	ACH-000884	Skin Cancer	CCLE	HRSTLRNLQ	DEG_APCC_DBOX_1	0.2778
p.N163Y	ACH-002159	Skin Cancer	CCLE	HRSTLRNLQ	DEG_APCC_DBOX_1	0.2778
p.N163Y	M14	skin	COSMIC	HRSTLRNLQ	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z3H4	Sterile alpha motif domain-containing protein 7	DEG_APCC_DBOX_1	153:161	HRSTLRNLQ	APC,CDC20,FZR1	0.7515	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: HRSTLRNLQ

Degron related mutations and impact score

Drug responses associated with SAMD7 mutations

All proteins holding degron of HRSTLRNLQ