DegronMD - Q7Z3Y8(KRT27)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E306K	TCGA-4Z-AA7Q	BLCA	TCGA	ARNELIEMK	DEG_APCC_DBOX_1	300:308	Mutation altering degron motif	0.591
p.E306K	DO218980	BLCA	ICGC	ARNELIEMK	DEG_APCC_DBOX_1	300:308	Mutation altering degron motif	0.591
p.E306K	DO234387	ESAD	ICGC	ARNELIEMK	DEG_APCC_DBOX_1	300:308	Mutation altering degron motif	0.591
p.E306K	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	ARNELIEMK	DEG_APCC_DBOX_1	300:308	Mutation altering degron motif	0.591
p.E306K	ACH-002263	Esophageal Cancer	CCLE	ARNELIEMK	DEG_APCC_DBOX_1	300:308	Mutation altering degron motif	0.591
p.E306K	KYSE-220	oesophagus	COSMIC	ARNELIEMK	DEG_APCC_DBOX_1	300:308	Mutation altering degron motif	0.591
p.N302S	TCGA-5M-AAT4	COAD	TCGA	ARNELIEMK	DEG_APCC_DBOX_1	300:308	Mutation altering degron motif	0.5958
p.N302S	DO223702	COAD	ICGC	ARNELIEMK	DEG_APCC_DBOX_1	300:308	Mutation altering degron motif	0.5958
p.T297A	TCGA-AY-6197	COAD	TCGA	ARNELIEMK	DEG_APCC_DBOX_1	300:308	Mutation rewiring degron network	0.25
p.T297A	DO9956	COAD	ICGC	ARNELIEMK	DEG_APCC_DBOX_1	300:308	Mutation rewiring degron network	0.25
p.R301L	TCGA-DA-A1I1	SKCM	TCGA	ARNELIEMK	DEG_APCC_DBOX_1	300:308	Mutation altering degron motif	0.8428
p.R301L	DO37966	SKCM	ICGC	ARNELIEMK	DEG_APCC_DBOX_1	300:308	Mutation altering degron motif	0.8428
p.L314H	TCGA-F9-A8NY	KIRP	TCGA	ARNELIEMK	DEG_APCC_DBOX_1	300:308	Mutation rewiring degron network	0.1667
p.L314H	DO48484	KIRP	ICGC	ARNELIEMK	DEG_APCC_DBOX_1	300:308	Mutation rewiring degron network	0.1667
p.M307I	TCGA-W3-AA1V	SKCM	TCGA	ARNELIEMK	DEG_APCC_DBOX_1	300:308	Mutation altering degron motif	0.6507
p.M307I	DO51276	SKCM	ICGC	ARNELIEMK	DEG_APCC_DBOX_1	300:308	Mutation altering degron motif	0.6507
p.I305T	DO229010	COCA	ICGC	ARNELIEMK	DEG_APCC_DBOX_1	300:308	Mutation altering degron motif	0.5966
p.I305T	DO229013	COCA	ICGC	ARNELIEMK	DEG_APCC_DBOX_1	300:308	Mutation altering degron motif	0.5966
p.I305T	DO229016	COCA	ICGC	ARNELIEMK	DEG_APCC_DBOX_1	300:308	Mutation altering degron motif	0.5966
p.I305T	DO229003	COCA	ICGC	ARNELIEMK	DEG_APCC_DBOX_1	300:308	Mutation altering degron motif	0.5966
p.I305T	DO229005	COCA	ICGC	ARNELIEMK	DEG_APCC_DBOX_1	300:308	Mutation altering degron motif	0.5966
p.A296T	DO233898	GACA	ICGC	ARNELIEMK	DEG_APCC_DBOX_1	300:308	Mutation rewiring degron network	0.2222
p.L304I	DO228952	LICA	ICGC	ARNELIEMK	DEG_APCC_DBOX_1	300:308	Mutation altering degron motif	0.7174
p.S291F	DO222875	MELA	ICGC	ARNELIEMK	DEG_APCC_DBOX_1	300:308	Mutation rewiring degron network	0.0833
p.L304F	SIDM01286	Esophageal Carcinoma	GDSC	ARNELIEMK	DEG_APCC_DBOX_1	300:308	Mutation altering degron motif	0.6981
p.R309H	SIDM01107	Melanoma	GDSC	ARNELIEMK	DEG_APCC_DBOX_1	300:308	Mutation rewiring degron network	0.3056
p.R309H	ACH-000465	Skin Cancer	CCLE	ARNELIEMK	DEG_APCC_DBOX_1	300:308	Mutation rewiring degron network	0.3056
p.R309H	SK-MEL-1	skin	COSMIC	ARNELIEMK	DEG_APCC_DBOX_1	300:308	Mutation rewiring degron network	0.3056

Kaplan plot for KRT27 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KRT27

UniProt ID: Q7Z3Y8

Entrez ID: 342574

Protein name: Keratin, type I cytoskeletal 27 (Cytokeratin-27) (CK-27) (Keratin-25C) (K25C) (Keratin-27) (K27) (Type I inner root sheath-specific keratin-K25irs3)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for KRT27 in