DegronMD

Uniprot ID: Q7Z3Y8

Source protein: Keratin, type I cytoskeletal 27

Source gene: KRT27

Class: DEG_APCC_DBOX_1

Location: 300:308

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6768

ASA_SCORE: 100.5444

COIL: 0.0277

CONS_SCORE: 0.5125

DSS_SCORE: 0.396

HELIX: 0.9726

FCONS_SCORE: 1.0877

RIG_SCORE: 0.8061

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E306K	TCGA-4Z-AA7Q	BLCA	TCGA	ARNELIEMK	DEG_APCC_DBOX_1	0.591
p.E306K	DO218980	BLCA	ICGC	ARNELIEMK	DEG_APCC_DBOX_1	0.591
p.E306K	DO234387	ESAD	ICGC	ARNELIEMK	DEG_APCC_DBOX_1	0.591
p.E306K	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	ARNELIEMK	DEG_APCC_DBOX_1	0.591
p.E306K	ACH-002263	Esophageal Cancer	CCLE	ARNELIEMK	DEG_APCC_DBOX_1	0.591
p.E306K	KYSE-220	oesophagus	COSMIC	ARNELIEMK	DEG_APCC_DBOX_1	0.591
p.N302S	TCGA-5M-AAT4	COAD	TCGA	ARNELIEMK	DEG_APCC_DBOX_1	0.5958
p.N302S	DO223702	COAD	ICGC	ARNELIEMK	DEG_APCC_DBOX_1	0.5958
p.T297A	TCGA-AY-6197	COAD	TCGA	ARNELIEMK	DEG_APCC_DBOX_1	0.25
p.T297A	DO9956	COAD	ICGC	ARNELIEMK	DEG_APCC_DBOX_1	0.25
p.R301L	TCGA-DA-A1I1	SKCM	TCGA	ARNELIEMK	DEG_APCC_DBOX_1	0.8428
p.R301L	DO37966	SKCM	ICGC	ARNELIEMK	DEG_APCC_DBOX_1	0.8428
p.L314H	TCGA-F9-A8NY	KIRP	TCGA	ARNELIEMK	DEG_APCC_DBOX_1	0.1667
p.L314H	DO48484	KIRP	ICGC	ARNELIEMK	DEG_APCC_DBOX_1	0.1667
p.M307I	TCGA-W3-AA1V	SKCM	TCGA	ARNELIEMK	DEG_APCC_DBOX_1	0.6507
p.M307I	DO51276	SKCM	ICGC	ARNELIEMK	DEG_APCC_DBOX_1	0.6507
p.I305T	DO229010	COCA	ICGC	ARNELIEMK	DEG_APCC_DBOX_1	0.5966
p.I305T	DO229013	COCA	ICGC	ARNELIEMK	DEG_APCC_DBOX_1	0.5966
p.I305T	DO229016	COCA	ICGC	ARNELIEMK	DEG_APCC_DBOX_1	0.5966
p.I305T	DO229003	COCA	ICGC	ARNELIEMK	DEG_APCC_DBOX_1	0.5966
p.I305T	DO229005	COCA	ICGC	ARNELIEMK	DEG_APCC_DBOX_1	0.5966
p.A296T	DO233898	GACA	ICGC	ARNELIEMK	DEG_APCC_DBOX_1	0.2222
p.L304I	DO228952	LICA	ICGC	ARNELIEMK	DEG_APCC_DBOX_1	0.7174
p.S291F	DO222875	MELA	ICGC	ARNELIEMK	DEG_APCC_DBOX_1	0.0833
p.L304F	SIDM01286	Esophageal Carcinoma	GDSC	ARNELIEMK	DEG_APCC_DBOX_1	0.6981
p.R309H	SIDM01107	Melanoma	GDSC	ARNELIEMK	DEG_APCC_DBOX_1	0.3056
p.R309H	ACH-000465	Skin Cancer	CCLE	ARNELIEMK	DEG_APCC_DBOX_1	0.3056
p.R309H	SK-MEL-1	skin	COSMIC	ARNELIEMK	DEG_APCC_DBOX_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARNELIEMK

Degron related mutations and impact score

Drug responses associated with KRT27 mutations

All proteins holding degron of ARNELIEMK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z3Y8	Keratin, type I cytoskeletal 27	DEG_APCC_DBOX_1	300:308	ARNELIEMK	APC,CDC20,FZR1	0.6768	More...