DegronMD - Q7Z3Y9(KRT26)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E314Q	TCGA-38-4625	LUAD	TCGA	ARNELTELK	DEG_APCC_DBOX_1	299:307	Mutation rewiring degron network	0.1389
p.E314Q	DO23952	LUAD	ICGC	ARNELTELK	DEG_APCC_DBOX_1	299:307	Mutation rewiring degron network	0.1389
p.L310M	TCGA-AP-A0LM	UCEC	TCGA	ARNELTELK	DEG_APCC_DBOX_1	299:307	Mutation rewiring degron network	0.25
p.L310M	DO43306	UCEC	ICGC	ARNELTELK	DEG_APCC_DBOX_1	299:307	Mutation rewiring degron network	0.25
p.E305K	TCGA-BS-A0UV	UCEC	TCGA	ARNELTELK	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.591
p.E305K	TCGA-ER-A194	SKCM	TCGA	ARNELTELK	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.591
p.E305K	TCGA-WE-A8K1	SKCM	TCGA	ARNELTELK	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.591
p.E305K	DO222884	COCA	ICGC	ARNELTELK	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.591
p.E305K	DO220891	MELA	ICGC	ARNELTELK	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.591
p.E305K	DO47646	SKCM	ICGC	ARNELTELK	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.591
p.E305K	DO51280	SKCM	ICGC	ARNELTELK	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.591
p.E305K	DO42793	UCEC	ICGC	ARNELTELK	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.591
p.E305K	SIDM00118	Colorectal Carcinoma	GDSC	ARNELTELK	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.591
p.E305K	ACH-001081	Colon/Colorectal Cancer	CCLE	ARNELTELK	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.591
p.E305K	HCC2998	large intestine	COSMIC	ARNELTELK	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.591
p.R308C	TCGA-CQ-6228	HNSC	TCGA	ARNELTELK	DEG_APCC_DBOX_1	299:307	Mutation rewiring degron network	0.3056
p.R308C	DO222884	COCA	ICGC	ARNELTELK	DEG_APCC_DBOX_1	299:307	Mutation rewiring degron network	0.3056
p.R308C	DO234370	ESAD	ICGC	ARNELTELK	DEG_APCC_DBOX_1	299:307	Mutation rewiring degron network	0.3056
p.R308C	DO14750	HNSC	ICGC	ARNELTELK	DEG_APCC_DBOX_1	299:307	Mutation rewiring degron network	0.3056
p.R308C	DO33091	PACA	ICGC	ARNELTELK	DEG_APCC_DBOX_1	299:307	Mutation rewiring degron network	0.3056
p.L317I	DO229022	LICA	ICGC	ARNELTELK	DEG_APCC_DBOX_1	299:307	Mutation rewiring degron network	0.0556
p.R308S	DO229045	LICA	ICGC	ARNELTELK	DEG_APCC_DBOX_1	299:307	Mutation rewiring degron network	0.3056
p.D291N	DO229063	LICA	ICGC	ARNELTELK	DEG_APCC_DBOX_1	299:307	Mutation rewiring degron network	0.1111
p.A296V	DO33084	PACA	ICGC	ARNELTELK	DEG_APCC_DBOX_1	299:307	Mutation rewiring degron network	0.25
p.E316Q	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	ARNELTELK	DEG_APCC_DBOX_1	299:307	Mutation rewiring degron network	0.0833
p.R300K	SIDM01588	Endometrial Carcinoma	GDSC	ARNELTELK	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.7237
p.R300K	ACH-000993	Endometrial/Uterine Cancer	CCLE	ARNELTELK	DEG_APCC_DBOX_1	299:307	Mutation altering degron motif	0.7237

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KRT26

UniProt ID: Q7Z3Y9

Entrez ID: 353288

Protein name: Keratin, type I cytoskeletal 26 (Cytokeratin-26) (CK-26) (Keratin-25B) (K25B) (Keratin-26) (K26) (Type I inner root sheath-specific keratin-K25irs2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KRT26 in