DegronMD

Uniprot ID: Q7Z3Y9

Source protein: Keratin, type I cytoskeletal 26

Source gene: KRT26

Class: DEG_APCC_DBOX_1

Location: 299:307

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5912

ASA_SCORE: 99.7222

COIL: 0.0326

CONS_SCORE: 0.7178

DSS_SCORE: 0.3859

HELIX: 0.9679

FCONS_SCORE: 1.0703

RIG_SCORE: 0.793

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E314Q	TCGA-38-4625	LUAD	TCGA	ARNELTELK	DEG_APCC_DBOX_1	0.1389
p.E314Q	DO23952	LUAD	ICGC	ARNELTELK	DEG_APCC_DBOX_1	0.1389
p.L310M	TCGA-AP-A0LM	UCEC	TCGA	ARNELTELK	DEG_APCC_DBOX_1	0.25
p.L310M	DO43306	UCEC	ICGC	ARNELTELK	DEG_APCC_DBOX_1	0.25
p.E305K	TCGA-BS-A0UV	UCEC	TCGA	ARNELTELK	DEG_APCC_DBOX_1	0.591
p.E305K	TCGA-ER-A194	SKCM	TCGA	ARNELTELK	DEG_APCC_DBOX_1	0.591
p.E305K	TCGA-WE-A8K1	SKCM	TCGA	ARNELTELK	DEG_APCC_DBOX_1	0.591
p.E305K	DO222884	COCA	ICGC	ARNELTELK	DEG_APCC_DBOX_1	0.591
p.E305K	DO220891	MELA	ICGC	ARNELTELK	DEG_APCC_DBOX_1	0.591
p.E305K	DO47646	SKCM	ICGC	ARNELTELK	DEG_APCC_DBOX_1	0.591
p.E305K	DO51280	SKCM	ICGC	ARNELTELK	DEG_APCC_DBOX_1	0.591
p.E305K	DO42793	UCEC	ICGC	ARNELTELK	DEG_APCC_DBOX_1	0.591
p.E305K	SIDM00118	Colorectal Carcinoma	GDSC	ARNELTELK	DEG_APCC_DBOX_1	0.591
p.E305K	ACH-001081	Colon/Colorectal Cancer	CCLE	ARNELTELK	DEG_APCC_DBOX_1	0.591
p.E305K	HCC2998	large_intestine	COSMIC	ARNELTELK	DEG_APCC_DBOX_1	0.591
p.R308C	TCGA-CQ-6228	HNSC	TCGA	ARNELTELK	DEG_APCC_DBOX_1	0.3056
p.R308C	DO222884	COCA	ICGC	ARNELTELK	DEG_APCC_DBOX_1	0.3056
p.R308C	DO234370	ESAD	ICGC	ARNELTELK	DEG_APCC_DBOX_1	0.3056
p.R308C	DO14750	HNSC	ICGC	ARNELTELK	DEG_APCC_DBOX_1	0.3056
p.R308C	DO33091	PACA	ICGC	ARNELTELK	DEG_APCC_DBOX_1	0.3056
p.L317I	DO229022	LICA	ICGC	ARNELTELK	DEG_APCC_DBOX_1	0.0556
p.R308S	DO229045	LICA	ICGC	ARNELTELK	DEG_APCC_DBOX_1	0.3056
p.D291N	DO229063	LICA	ICGC	ARNELTELK	DEG_APCC_DBOX_1	0.1111
p.A296V	DO33084	PACA	ICGC	ARNELTELK	DEG_APCC_DBOX_1	0.25
p.E316Q	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	ARNELTELK	DEG_APCC_DBOX_1	0.0833
p.R300K	SIDM01588	Endometrial Carcinoma	GDSC	ARNELTELK	DEG_APCC_DBOX_1	0.7237
p.R300K	ACH-000993	Endometrial/Uterine Cancer	CCLE	ARNELTELK	DEG_APCC_DBOX_1	0.7237

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z3Y9	Keratin, type I cytoskeletal 26	DEG_APCC_DBOX_1	299:307	ARNELTELK	APC,CDC20,FZR1	0.5912	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARNELTELK

Degron related mutations and impact score

Drug responses associated with KRT26 mutations

All proteins holding degron of ARNELTELK