DegronMD - Q7Z3Z2(RD3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T70S	TCGA-77-A5GH	LUSC	TCGA	LASTPRST	DEG_SCF_FBW7_1	63:70	Mutation altering degron motif	0.6005
p.T70S	DO45452	LUSC	ICGC	LASTPRST	DEG_SCF_FBW7_1	63:70	Mutation altering degron motif	0.6005
p.R78W	TCGA-AD-6964	COAD	TCGA	LASTPRST	DEG_SCF_FBW7_1	63:70	Mutation rewiring degron network	0.1111
p.R78W	TCGA-G4-6302	COAD	TCGA	LASTPRST	DEG_SCF_FBW7_1	63:70	Mutation rewiring degron network	0.1111
p.R78W	DO8778	COAD	ICGC	LASTPRST	DEG_SCF_FBW7_1	63:70	Mutation rewiring degron network	0.1111
p.R78W	DO8360	COAD	ICGC	LASTPRST	DEG_SCF_FBW7_1	63:70	Mutation rewiring degron network	0.1111
p.R78W	DO230346	COCA	ICGC	LASTPRST	DEG_SCF_FBW7_1	63:70	Mutation rewiring degron network	0.1111
p.R78W	DO233213	GACA	ICGC	LASTPRST	DEG_SCF_FBW7_1	63:70	Mutation rewiring degron network	0.1111
p.G57S	TCGA-AJ-A3BH	UCEC	TCGA	LASTPRST	DEG_SCF_FBW7_1	63:70	Mutation rewiring degron network	0.1667
p.G57S	DO41638	UCEC	ICGC	LASTPRST	DEG_SCF_FBW7_1	63:70	Mutation rewiring degron network	0.1667
p.R68Q	TCGA-AX-A2HD	UCEC	TCGA	LASTPRST	DEG_SCF_FBW7_1	63:70	Mutation altering degron motif	0.6218
p.R68Q	TCGA-D7-5578	STAD	TCGA	LASTPRST	DEG_SCF_FBW7_1	63:70	Mutation altering degron motif	0.6218
p.R68Q	DO38475	STAD	ICGC	LASTPRST	DEG_SCF_FBW7_1	63:70	Mutation altering degron motif	0.6218
p.R68Q	DO42608	UCEC	ICGC	LASTPRST	DEG_SCF_FBW7_1	63:70	Mutation altering degron motif	0.6218
p.R68Q	SIDM01770	Gastric Carcinoma	GDSC	LASTPRST	DEG_SCF_FBW7_1	63:70	Mutation altering degron motif	0.6218
p.R68Q	ACH-000908	Gastric Cancer	CCLE	LASTPRST	DEG_SCF_FBW7_1	63:70	Mutation altering degron motif	0.6218
p.P67S	DO234308	ESAD	ICGC	LASTPRST	DEG_SCF_FBW7_1	63:70	Mutation altering degron motif	0.6752
p.G57V	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	LASTPRST	DEG_SCF_FBW7_1	63:70	Mutation rewiring degron network	0.1667
p.G57V	ACH-002220	Lymphoma	CCLE	LASTPRST	DEG_SCF_FBW7_1	63:70	Mutation rewiring degron network	0.1667
p.G57V	CRO-AP2	haematopoietic and lymphoid tissue	COSMIC	LASTPRST	DEG_SCF_FBW7_1	63:70	Mutation rewiring degron network	0.1667
p.P75R	ACH-001366	Neuroblastoma	CCLE	LASTPRST	DEG_SCF_FBW7_1	63:70	Mutation rewiring degron network	0.1944

Kaplan plot for RD3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RD3

UniProt ID: Q7Z3Z2

Entrez ID: 343035

Protein name: Protein RD3 (Retinal degeneration protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RD3 in