DegronMD

Uniprot ID: Q7Z3Z2

Source protein: Protein RD3

Source gene: RD3

Class: DEG_SCF_FBW7_1

Location: 63:70

E3 ligase: FBXW7

DEGRON score: 0.5063

ASA_SCORE: 73.9875

COIL: 0.8436

CONS_SCORE: 0.6284

DSS_SCORE: 0.232

HELIX: 0.1011

FCONS_SCORE: 0.895

RIG_SCORE: 0.7793

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T70S	TCGA-77-A5GH	LUSC	TCGA	LASTPRST	DEG_SCF_FBW7_1	0.6005
p.T70S	DO45452	LUSC	ICGC	LASTPRST	DEG_SCF_FBW7_1	0.6005
p.R78W	TCGA-AD-6964	COAD	TCGA	LASTPRST	DEG_SCF_FBW7_1	0.1111
p.R78W	TCGA-G4-6302	COAD	TCGA	LASTPRST	DEG_SCF_FBW7_1	0.1111
p.R78W	DO8778	COAD	ICGC	LASTPRST	DEG_SCF_FBW7_1	0.1111
p.R78W	DO8360	COAD	ICGC	LASTPRST	DEG_SCF_FBW7_1	0.1111
p.R78W	DO230346	COCA	ICGC	LASTPRST	DEG_SCF_FBW7_1	0.1111
p.R78W	DO233213	GACA	ICGC	LASTPRST	DEG_SCF_FBW7_1	0.1111
p.G57S	TCGA-AJ-A3BH	UCEC	TCGA	LASTPRST	DEG_SCF_FBW7_1	0.1667
p.G57S	DO41638	UCEC	ICGC	LASTPRST	DEG_SCF_FBW7_1	0.1667
p.R68Q	TCGA-AX-A2HD	UCEC	TCGA	LASTPRST	DEG_SCF_FBW7_1	0.6218
p.R68Q	TCGA-D7-5578	STAD	TCGA	LASTPRST	DEG_SCF_FBW7_1	0.6218
p.R68Q	DO38475	STAD	ICGC	LASTPRST	DEG_SCF_FBW7_1	0.6218
p.R68Q	DO42608	UCEC	ICGC	LASTPRST	DEG_SCF_FBW7_1	0.6218
p.R68Q	SIDM01770	Gastric Carcinoma	GDSC	LASTPRST	DEG_SCF_FBW7_1	0.6218
p.R68Q	ACH-000908	Gastric Cancer	CCLE	LASTPRST	DEG_SCF_FBW7_1	0.6218
p.P67S	DO234308	ESAD	ICGC	LASTPRST	DEG_SCF_FBW7_1	0.6752
p.G57V	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	LASTPRST	DEG_SCF_FBW7_1	0.1667
p.G57V	ACH-002220	Lymphoma	CCLE	LASTPRST	DEG_SCF_FBW7_1	0.1667
p.G57V	CRO-AP2	haematopoietic_and_lymphoid_tissue	COSMIC	LASTPRST	DEG_SCF_FBW7_1	0.1667
p.P75R	ACH-001366	Neuroblastoma	CCLE	LASTPRST	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z3Z2	Protein RD3	DEG_SCF_FBW7_1	63:70	LASTPRST	FBXW7	0.5063	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons