DegronMD - Q7Z3Z4(PIWIL4)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D79E	TCGA-78-7146	LUAD	TCGA	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.1111
p.D79E	DO23717	LUAD	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.1111
p.T87A	TCGA-AJ-A3EL	UCEC	TCGA	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.6028
p.T87A	DO41542	UCEC	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.6028
p.E89K	TCGA-FI-A2D0	UCEC	TCGA	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.591
p.E89K	DO43891	UCEC	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.591
p.S101Y	TCGA-IB-7651	PAAD	TCGA	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.1667
p.S101Y	DO46657	PAAD	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.1667
p.C86S	TCGA-ZS-A9CF	LIHC	TCGA	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.3056
p.C86S	DO49722	LIHC	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.3056
p.R88T	DO48372	BLCA	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.7876
p.V98I	DO222973	BTCA	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation substituting flanking lysine	0.3611
p.S78L	DO8818	COAD	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.0833
p.H93Y	DO230309	COCA	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.6118
p.M87I	DO228935	COCA	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.7618
p.G104D	DO21487	LAML	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.0833
p.G104V	DO229019	LICA	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.0833
p.V94L	DO229026	LICA	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.5654
p.V81L	DO44846	LICA	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.1667
p.Q99K	DO52292	LIHC	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.2222
p.N95S	DO45107	LIRI	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.7069
p.R96P	DO224605	LUSC	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.3056
p.R96H	DO46424	OV	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.3056
p.P102S	DO37429	SKCM	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation blocking phosphorylation signal	0.5833
p.E93K	DO37499	SKCM	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.7022
p.E93K	DO51267	SKCM	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.7022
p.F90L	DO50076	UCEC	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.6981
p.R96C	DO41133	UCEC	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.3056
p.T105N	DO41361	UCEC	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.0556
p.G103V	DO229086	UTCA	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.1111
p.I104T	SIDM00917	Acute Myeloid Leukemia	GDSC	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.0833
p.I104T	ACH-002218	Leukemia	CCLE	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.0833
p.I104T	CESS	haematopoietic and lymphoid tissue	COSMIC	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.0833
p.Q78R	SIDM00493	Other Solid Cancers	GDSC	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.0833
p.R89Q	SW1783	central nervous system	COSMIC	TREKLAHVR	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.7329

Kaplan plot for PIWIL4 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PIWIL4

UniProt ID: Q7Z3Z4

Entrez ID: 143689

Protein name: Piwi-like protein 4

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PIWIL4 in