DegronMD

Uniprot ID: Q7Z3Z4

Source protein: Piwi-like protein 4

Source gene: PIWIL4

Class: DEG_APCC_DBOX_1

Location: 87:95

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5006

ASA_SCORE: 104.0778

COIL: 0.7772

CONS_SCORE: 0.2936

DSS_SCORE: 0.1959

HELIX: 0.1232

FCONS_SCORE: 0.8792

RIG_SCORE: 0.8472

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D79E	TCGA-78-7146	LUAD	TCGA	TREKLAHVR	DEG_APCC_DBOX_1	0.1111
p.D79E	DO23717	LUAD	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	0.1111
p.T87A	TCGA-AJ-A3EL	UCEC	TCGA	TREKLAHVR	DEG_APCC_DBOX_1	0.6028
p.T87A	DO41542	UCEC	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	0.6028
p.E89K	TCGA-FI-A2D0	UCEC	TCGA	TREKLAHVR	DEG_APCC_DBOX_1	0.591
p.E89K	DO43891	UCEC	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	0.591
p.S101Y	TCGA-IB-7651	PAAD	TCGA	TREKLAHVR	DEG_APCC_DBOX_1	0.1667
p.S101Y	DO46657	PAAD	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	0.1667
p.C86S	TCGA-ZS-A9CF	LIHC	TCGA	TREKLAHVR	DEG_APCC_DBOX_1	0.3056
p.C86S	DO49722	LIHC	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	0.3056
p.R88T	DO48372	BLCA	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	0.7876
p.V98I	DO222973	BTCA	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	0.3611
p.S78L	DO8818	COAD	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	0.0833
p.H93Y	DO230309	COCA	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	0.6118
p.M87I	DO228935	COCA	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	0.7618
p.G104D	DO21487	LAML	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	0.0833
p.G104V	DO229019	LICA	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	0.0833
p.V94L	DO229026	LICA	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	0.5654
p.V81L	DO44846	LICA	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	0.1667
p.Q99K	DO52292	LIHC	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	0.2222
p.N95S	DO45107	LIRI	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	0.7069
p.R96P	DO224605	LUSC	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	0.3056
p.R96H	DO46424	OV	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	0.3056
p.P102S	DO37429	SKCM	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	0.5833
p.E93K	DO37499	SKCM	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	0.7022
p.E93K	DO51267	SKCM	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	0.7022
p.F90L	DO50076	UCEC	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	0.6981
p.R96C	DO41133	UCEC	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	0.3056
p.T105N	DO41361	UCEC	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	0.0556
p.G103V	DO229086	UTCA	ICGC	TREKLAHVR	DEG_APCC_DBOX_1	0.1111
p.I104T	SIDM00917	Acute Myeloid Leukemia	GDSC	TREKLAHVR	DEG_APCC_DBOX_1	0.0833
p.I104T	ACH-002218	Leukemia	CCLE	TREKLAHVR	DEG_APCC_DBOX_1	0.0833
p.I104T	CESS	haematopoietic_and_lymphoid_tissue	COSMIC	TREKLAHVR	DEG_APCC_DBOX_1	0.0833
p.Q78R	SIDM00493	Other Solid Cancers	GDSC	TREKLAHVR	DEG_APCC_DBOX_1	0.0833
p.R89Q	SW1783	central_nervous_system	COSMIC	TREKLAHVR	DEG_APCC_DBOX_1	0.7329

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TREKLAHVR

Degron related mutations and impact score

Drug responses associated with PIWIL4 mutations

All proteins holding degron of TREKLAHVR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z3Z4	Piwi-like protein 4	DEG_APCC_DBOX_1	87:95	TREKLAHVR	APC,CDC20,FZR1	0.5006	More...