DegronMD - Q7Z494(NPHP3)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K173N	TCGA-67-4679	LUAD	TCGA	FKIFRE	LIG_APCC_ABBA_1	172:177	Mutation altering degron motif	0.5806
p.K173N	DO23604	LUAD	ICGC	FKIFRE	LIG_APCC_ABBA_1	172:177	Mutation altering degron motif	0.5806
p.K167T	DO228650	LICA	ICGC	FKIFRE	LIG_APCC_ABBA_1	172:177	Mutation substituting flanking lysine	0.3056
p.K167T	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	FKIFRE	LIG_APCC_ABBA_1	172:177	Mutation substituting flanking lysine	0.3056
p.K167T	LU-99A	lung	COSMIC	FKIFRE	LIG_APCC_ABBA_1	172:177	Mutation substituting flanking lysine	0.3056
p.Q184H	DO46538	OV	ICGC	FKIFRE	LIG_APCC_ABBA_1	172:177	Mutation rewiring degron network	0.1389
p.D166H	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	FKIFRE	LIG_APCC_ABBA_1	172:177	Mutation rewiring degron network	0.1667
p.D166H	ACH-002220	Lymphoma	CCLE	FKIFRE	LIG_APCC_ABBA_1	172:177	Mutation rewiring degron network	0.1667
p.D166H	CRO-AP2	haematopoietic and lymphoid tissue	COSMIC	FKIFRE	LIG_APCC_ABBA_1	172:177	Mutation rewiring degron network	0.1667

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons