DegronMD

Uniprot ID: Q7Z494

Source protein: Nephrocystin-3

Source gene: NPHP3

Class: LIG_APCC_ABBA_1

Location: 172:177

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6237

ASA_SCORE: 98.4833

COIL: 0.4992

CONS_SCORE: 0.4746

DSS_SCORE: 0.3301

HELIX: 0.4687

FCONS_SCORE: 1.091

RIG_SCORE: 0.8268

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K173N	TCGA-67-4679	LUAD	TCGA	FKIFRE	LIG_APCC_ABBA_1	0.5806
p.K173N	DO23604	LUAD	ICGC	FKIFRE	LIG_APCC_ABBA_1	0.5806
p.K167T	DO228650	LICA	ICGC	FKIFRE	LIG_APCC_ABBA_1	0.3056
p.K167T	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	FKIFRE	LIG_APCC_ABBA_1	0.3056
p.K167T	LU-99A	lung	COSMIC	FKIFRE	LIG_APCC_ABBA_1	0.3056
p.Q184H	DO46538	OV	ICGC	FKIFRE	LIG_APCC_ABBA_1	0.1389
p.D166H	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	FKIFRE	LIG_APCC_ABBA_1	0.1667
p.D166H	ACH-002220	Lymphoma	CCLE	FKIFRE	LIG_APCC_ABBA_1	0.1667
p.D166H	CRO-AP2	haematopoietic_and_lymphoid_tissue	COSMIC	FKIFRE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z494	Nephrocystin-3	LIG_APCC_ABBA_1	172:177	FKIFRE	APC,CDC20,FZR1	0.6237	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons