DegronMD - Q7Z5B4(RIC3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K141E	TCGA-05-4389	LUAD	TCGA	DGKCYTAMP	CBL_PTK	127:135	Mutation substituting flanking lysine	0.2778
p.K141E	DO24307	LUAD	ICGC	DGKCYTAMP	CBL_PTK	127:135	Mutation substituting flanking lysine	0.2778
p.E126D	TCGA-EO-A22R	UCEC	TCGA	DGKCYTAMP	CBL_PTK	127:135	Mutation rewiring degron network	0.3056
p.E126D	DO42713	UCEC	ICGC	DGKCYTAMP	CBL_PTK	127:135	Mutation rewiring degron network	0.3056
p.E126K	TCGA-V1-A8ML	PRAD	TCGA	DGKCYTAMP	CBL_PTK	127:135	Mutation rewiring degron network	0.3056
p.E126K	DO219351	PRAD	ICGC	DGKCYTAMP	CBL_PTK	127:135	Mutation rewiring degron network	0.3056
p.E127K	DO48375	BLCA	ICGC	DGKCYTAMP	CBL_PTK	127:135	Mutation altering degron motif	0.7022
p.D133N	DO44141	BRCA	ICGC	DGKCYTAMP	CBL_PTK	127:135	Mutation altering degron motif	0.6932
p.L139V	DO3916	BRCA	ICGC	DGKCYTAMP	CBL_PTK	127:135	Mutation rewiring degron network	0.2222
p.C124S	DO10670	COAD	ICGC	DGKCYTAMP	CBL_PTK	127:135	Mutation rewiring degron network	0.25
p.K120N	DO222765	COCA	ICGC	DGKCYTAMP	CBL_PTK	127:135	Mutation substituting flanking lysine	0.25
p.I124L	DO222762	COCA	ICGC	DGKCYTAMP	CBL_PTK	127:135	Mutation rewiring degron network	0.25
p.E129K	DO14426	HNSC	ICGC	DGKCYTAMP	CBL_PTK	127:135	Mutation altering degron motif	0.7022
p.E129K	DO41644	UCEC	ICGC	DGKCYTAMP	CBL_PTK	127:135	Mutation altering degron motif	0.7022
p.P135S	DO229346	LAML	ICGC	DGKCYTAMP	CBL_PTK	127:135	Mutation altering degron motif	0.6752
p.C130Y	DO230659	LAML	ICGC	DGKCYTAMP	CBL_PTK	127:135	Mutation altering degron motif	0.5976
p.C130Y	DO231140	LAML	ICGC	DGKCYTAMP	CBL_PTK	127:135	Mutation altering degron motif	0.5976
p.A133D	DO228974	LICA	ICGC	DGKCYTAMP	CBL_PTK	127:135	Mutation altering degron motif	0.6682
p.T132N	DO229025	LICA	ICGC	DGKCYTAMP	CBL_PTK	127:135	Mutation altering degron motif	0.7055
p.G121A	DO230990	LUSC	ICGC	DGKCYTAMP	CBL_PTK	127:135	Mutation rewiring degron network	0.1667
p.K117N	DO26500	LUSC	ICGC	DGKCYTAMP	CBL_PTK	127:135	Mutation substituting flanking lysine	0.1667
p.G136E	DO220902	MELA	ICGC	DGKCYTAMP	CBL_PTK	127:135	Mutation rewiring degron network	0.3056
p.A138P	DO28813	OV	ICGC	DGKCYTAMP	CBL_PTK	127:135	Mutation rewiring degron network	0.25
p.L123P	DO35083	PACA	ICGC	DGKCYTAMP	CBL_PTK	127:135	Mutation rewiring degron network	0.2222
p.H127N	DO35460	PACA	ICGC	DGKCYTAMP	CBL_PTK	127:135	Mutation altering degron motif	0.7423
p.A132V	DO42280	UCEC	ICGC	DGKCYTAMP	CBL_PTK	127:135	Mutation altering degron motif	0.6936
p.C121R	DO43298	UCEC	ICGC	DGKCYTAMP	CBL_PTK	127:135	Mutation rewiring degron network	0.1667
p.A135V	DO42472	UCEC	ICGC	DGKCYTAMP	CBL_PTK	127:135	Mutation altering degron motif	0.6936
p.I142T	SIDM00477	Esophageal Carcinoma	GDSC	DGKCYTAMP	CBL_PTK	127:135	Mutation rewiring degron network	0.1389
p.I142T	ACH-000383	Esophageal Cancer	CCLE	DGKCYTAMP	CBL_PTK	127:135	Mutation rewiring degron network	0.1389
p.I142T	OE33	oesophagus	COSMIC	DGKCYTAMP	CBL_PTK	127:135	Mutation rewiring degron network	0.1389
p.M134V	SIDM00151	Ovarian Carcinoma	GDSC	DGKCYTAMP	CBL_PTK	127:135	Mutation altering degron motif	0.6097
p.M134V	ACH-000966	Ovarian Cancer	CCLE	DGKCYTAMP	CBL_PTK	127:135	Mutation altering degron motif	0.6097
p.M134V	IGROV-1	ovary	COSMIC	DGKCYTAMP	CBL_PTK	127:135	Mutation altering degron motif	0.6097
p.G128E	SIDM00217	Colorectal Carcinoma	GDSC	DGKCYTAMP	CBL_PTK	127:135	Mutation altering degron motif	0.6087
p.G128E	ACH-000999	Colon/Colorectal Cancer	CCLE	DGKCYTAMP	CBL_PTK	127:135	Mutation altering degron motif	0.6087
p.G128E	ACH-002005	Skin Cancer	CCLE	DGKCYTAMP	CBL_PTK	127:135	Mutation altering degron motif	0.6087
p.G128E	SNU-1040	large intestine	COSMIC	DGKCYTAMP	CBL_PTK	127:135	Mutation altering degron motif	0.6087
p.H139P	ACH-001991	Primary	CCLE	DGKCYTAMP	CBL_PTK	127:135	Mutation rewiring degron network	0.2222
p.F125L	Sarc9371	bone	COSMIC	DGKCYTAMP	CBL_PTK	127:135	Mutation rewiring degron network	0.2778

Kaplan plot for RIC3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RIC3

UniProt ID: Q7Z5B4

Entrez ID: 79608

Protein name: Protein RIC-3 (Resistant to inhibitor of cholinesterase 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RIC3 in