DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DGKCYTAMP
Uniprot ID:
Q7Z5B4
Source protein:
Protein RIC-3
Source gene:
RIC3
Class:
CBL_PTK
Location:
127:135
E3 ligase:
CBL
DEGRON score:
0.9541
ASA_SCORE:
82.7222
COIL:
0.832
CONS_SCORE:
0.4784
DSS_SCORE:
0.3693
HELIX:
0.05
FCONS_SCORE:
0.7303
RIG_SCORE:
0.7865
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.H127N
DO35460
PACA
ICGC
DGKCYTAMP
CBL_PTK
0.7423
p.T132N
DO229025
LICA
ICGC
DGKCYTAMP
CBL_PTK
0.7055
p.E127K
DO48375
BLCA
ICGC
DGKCYTAMP
CBL_PTK
0.7022
p.E129K
DO14426
HNSC
ICGC
DGKCYTAMP
CBL_PTK
0.7022
p.E129K
DO41644
UCEC
ICGC
DGKCYTAMP
CBL_PTK
0.7022
p.A132V
DO42280
UCEC
ICGC
DGKCYTAMP
CBL_PTK
0.6936
p.A135V
DO42472
UCEC
ICGC
DGKCYTAMP
CBL_PTK
0.6936
p.D133N
DO44141
BRCA
ICGC
DGKCYTAMP
CBL_PTK
0.6932
p.P135S
DO229346
LAML
ICGC
DGKCYTAMP
CBL_PTK
0.6752
p.A133D
DO228974
LICA
ICGC
DGKCYTAMP
CBL_PTK
0.6682
p.M134V
SIDM00151
Ovarian Carcinoma
GDSC
DGKCYTAMP
CBL_PTK
0.6097
p.M134V
ACH-000966
Ovarian Cancer
CCLE
DGKCYTAMP
CBL_PTK
0.6097
p.M134V
IGROV-1
ovary
COSMIC
DGKCYTAMP
CBL_PTK
0.6097
p.G128E
SIDM00217
Colorectal Carcinoma
GDSC
DGKCYTAMP
CBL_PTK
0.6087
p.G128E
ACH-000999
Colon/Colorectal Cancer
CCLE
DGKCYTAMP
CBL_PTK
0.6087
p.G128E
ACH-002005
Skin Cancer
CCLE
DGKCYTAMP
CBL_PTK
0.6087
p.G128E
SNU-1040
large_intestine
COSMIC
DGKCYTAMP
CBL_PTK
0.6087
p.C130Y
DO230659
LAML
ICGC
DGKCYTAMP
CBL_PTK
0.5976
p.C130Y
DO231140
LAML
ICGC
DGKCYTAMP
CBL_PTK
0.5976
p.E126D
TCGA-EO-A22R
UCEC
TCGA
DGKCYTAMP
CBL_PTK
0.3056
p.E126D
DO42713
UCEC
ICGC
DGKCYTAMP
CBL_PTK
0.3056
p.E126K
TCGA-V1-A8ML
PRAD
TCGA
DGKCYTAMP
CBL_PTK
0.3056
p.E126K
DO219351
PRAD
ICGC
DGKCYTAMP
CBL_PTK
0.3056
p.G136E
DO220902
MELA
ICGC
DGKCYTAMP
CBL_PTK
0.3056
p.K141E
TCGA-05-4389
LUAD
TCGA
DGKCYTAMP
CBL_PTK
0.2778
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Drug responses associated with RIC3 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of DGKCYTAMP
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q7Z5B4
Protein RIC-3
CBL_PTK
127:135
DGKCYTAMP
CBL
0.9541
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