DegronMD

Uniprot ID: Q7Z5B4

Source protein: Protein RIC-3

Source gene: RIC3

Class: CBL_PTK

Location: 127:135

E3 ligase: CBL

DEGRON score: 0.9541

ASA_SCORE: 82.7222

COIL: 0.832

CONS_SCORE: 0.4784

DSS_SCORE: 0.3693

HELIX: 0.05

FCONS_SCORE: 0.7303

RIG_SCORE: 0.7865

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K141E	TCGA-05-4389	LUAD	TCGA	DGKCYTAMP	CBL_PTK	0.2778
p.K141E	DO24307	LUAD	ICGC	DGKCYTAMP	CBL_PTK	0.2778
p.E126D	TCGA-EO-A22R	UCEC	TCGA	DGKCYTAMP	CBL_PTK	0.3056
p.E126D	DO42713	UCEC	ICGC	DGKCYTAMP	CBL_PTK	0.3056
p.E126K	TCGA-V1-A8ML	PRAD	TCGA	DGKCYTAMP	CBL_PTK	0.3056
p.E126K	DO219351	PRAD	ICGC	DGKCYTAMP	CBL_PTK	0.3056
p.E127K	DO48375	BLCA	ICGC	DGKCYTAMP	CBL_PTK	0.7022
p.D133N	DO44141	BRCA	ICGC	DGKCYTAMP	CBL_PTK	0.6932
p.L139V	DO3916	BRCA	ICGC	DGKCYTAMP	CBL_PTK	0.2222
p.C124S	DO10670	COAD	ICGC	DGKCYTAMP	CBL_PTK	0.25
p.K120N	DO222765	COCA	ICGC	DGKCYTAMP	CBL_PTK	0.25
p.I124L	DO222762	COCA	ICGC	DGKCYTAMP	CBL_PTK	0.25
p.E129K	DO14426	HNSC	ICGC	DGKCYTAMP	CBL_PTK	0.7022
p.E129K	DO41644	UCEC	ICGC	DGKCYTAMP	CBL_PTK	0.7022
p.P135S	DO229346	LAML	ICGC	DGKCYTAMP	CBL_PTK	0.6752
p.C130Y	DO230659	LAML	ICGC	DGKCYTAMP	CBL_PTK	0.5976
p.C130Y	DO231140	LAML	ICGC	DGKCYTAMP	CBL_PTK	0.5976
p.A133D	DO228974	LICA	ICGC	DGKCYTAMP	CBL_PTK	0.6682
p.T132N	DO229025	LICA	ICGC	DGKCYTAMP	CBL_PTK	0.7055
p.G121A	DO230990	LUSC	ICGC	DGKCYTAMP	CBL_PTK	0.1667
p.K117N	DO26500	LUSC	ICGC	DGKCYTAMP	CBL_PTK	0.1667
p.G136E	DO220902	MELA	ICGC	DGKCYTAMP	CBL_PTK	0.3056
p.A138P	DO28813	OV	ICGC	DGKCYTAMP	CBL_PTK	0.25
p.L123P	DO35083	PACA	ICGC	DGKCYTAMP	CBL_PTK	0.2222
p.H127N	DO35460	PACA	ICGC	DGKCYTAMP	CBL_PTK	0.7423
p.A132V	DO42280	UCEC	ICGC	DGKCYTAMP	CBL_PTK	0.6936
p.C121R	DO43298	UCEC	ICGC	DGKCYTAMP	CBL_PTK	0.1667
p.A135V	DO42472	UCEC	ICGC	DGKCYTAMP	CBL_PTK	0.6936
p.I142T	SIDM00477	Esophageal Carcinoma	GDSC	DGKCYTAMP	CBL_PTK	0.1389
p.I142T	ACH-000383	Esophageal Cancer	CCLE	DGKCYTAMP	CBL_PTK	0.1389
p.I142T	OE33	oesophagus	COSMIC	DGKCYTAMP	CBL_PTK	0.1389
p.M134V	SIDM00151	Ovarian Carcinoma	GDSC	DGKCYTAMP	CBL_PTK	0.6097
p.M134V	ACH-000966	Ovarian Cancer	CCLE	DGKCYTAMP	CBL_PTK	0.6097
p.M134V	IGROV-1	ovary	COSMIC	DGKCYTAMP	CBL_PTK	0.6097
p.G128E	SIDM00217	Colorectal Carcinoma	GDSC	DGKCYTAMP	CBL_PTK	0.6087
p.G128E	ACH-000999	Colon/Colorectal Cancer	CCLE	DGKCYTAMP	CBL_PTK	0.6087
p.G128E	ACH-002005	Skin Cancer	CCLE	DGKCYTAMP	CBL_PTK	0.6087
p.G128E	SNU-1040	large_intestine	COSMIC	DGKCYTAMP	CBL_PTK	0.6087
p.H139P	ACH-001991	Primary	CCLE	DGKCYTAMP	CBL_PTK	0.2222
p.F125L	Sarc9371	bone	COSMIC	DGKCYTAMP	CBL_PTK	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DGKCYTAMP

Degron related mutations and impact score

Drug responses associated with RIC3 mutations

All proteins holding degron of DGKCYTAMP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z5B4	Protein RIC-3	CBL_PTK	127:135	DGKCYTAMP	CBL	0.9541	More...