DegronMD - Q7Z5Q5(POLN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A750T	TCGA-59-2349	OV	TCGA	RRRPLPRIH	DEG_APCC_DBOX_1	741:749	Mutation rewiring degron network	0.3056
p.A750T	DO28621	OV	ICGC	RRRPLPRIH	DEG_APCC_DBOX_1	741:749	Mutation rewiring degron network	0.3056
p.G733C	TCGA-D3-A2JP	SKCM	TCGA	RRRPLPRIH	DEG_APCC_DBOX_1	741:749	Mutation rewiring degron network	0.1111
p.G733C	DO47407	SKCM	ICGC	RRRPLPRIH	DEG_APCC_DBOX_1	741:749	Mutation rewiring degron network	0.1111
p.G740D	TCGA-EE-A182	SKCM	TCGA	RRRPLPRIH	DEG_APCC_DBOX_1	741:749	Mutation rewiring degron network	0.3056
p.G740D	DO37814	SKCM	ICGC	RRRPLPRIH	DEG_APCC_DBOX_1	741:749	Mutation rewiring degron network	0.3056
p.Q731K	TCGA-ER-A2NF	SKCM	TCGA	RRRPLPRIH	DEG_APCC_DBOX_1	741:749	Mutation rewiring degron network	0.0556
p.Q731K	DO47451	SKCM	ICGC	RRRPLPRIH	DEG_APCC_DBOX_1	741:749	Mutation rewiring degron network	0.0556
p.P744S	DO230336	COCA	ICGC	RRRPLPRIH	DEG_APCC_DBOX_1	741:749	Mutation altering degron motif	0.5641
p.Q753R	DO48701	LIRI	ICGC	RRRPLPRIH	DEG_APCC_DBOX_1	741:749	Mutation rewiring degron network	0.2222
p.R743K	DO46396	OV	ICGC	RRRPLPRIH	DEG_APCC_DBOX_1	741:749	Mutation altering degron motif	0.6126
p.A757G	DO32984	PACA	ICGC	RRRPLPRIH	DEG_APCC_DBOX_1	741:749	Mutation rewiring degron network	0.1111
p.R756W	DO218863	SKCA	ICGC	RRRPLPRIH	DEG_APCC_DBOX_1	741:749	Mutation rewiring degron network	0.1389
p.H751Y	DO233981	THCA	ICGC	RRRPLPRIH	DEG_APCC_DBOX_1	741:749	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons