DegronMD

Uniprot ID: Q7Z5Q5

Source protein: DNA polymerase nu

Source gene: POLN

Class: DEG_APCC_DBOX_1

Location: 741:749

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6834

ASA_SCORE: 79.2111

COIL: 0.5414

CONS_SCORE: 0.488

DSS_SCORE: 0.3808

HELIX: 0.2032

FCONS_SCORE: 1.2928

RIG_SCORE: 0.7328

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A750T	TCGA-59-2349	OV	TCGA	RRRPLPRIH	DEG_APCC_DBOX_1	0.3056
p.A750T	DO28621	OV	ICGC	RRRPLPRIH	DEG_APCC_DBOX_1	0.3056
p.G733C	TCGA-D3-A2JP	SKCM	TCGA	RRRPLPRIH	DEG_APCC_DBOX_1	0.1111
p.G733C	DO47407	SKCM	ICGC	RRRPLPRIH	DEG_APCC_DBOX_1	0.1111
p.G740D	TCGA-EE-A182	SKCM	TCGA	RRRPLPRIH	DEG_APCC_DBOX_1	0.3056
p.G740D	DO37814	SKCM	ICGC	RRRPLPRIH	DEG_APCC_DBOX_1	0.3056
p.Q731K	TCGA-ER-A2NF	SKCM	TCGA	RRRPLPRIH	DEG_APCC_DBOX_1	0.0556
p.Q731K	DO47451	SKCM	ICGC	RRRPLPRIH	DEG_APCC_DBOX_1	0.0556
p.P744S	DO230336	COCA	ICGC	RRRPLPRIH	DEG_APCC_DBOX_1	0.5641
p.Q753R	DO48701	LIRI	ICGC	RRRPLPRIH	DEG_APCC_DBOX_1	0.2222
p.R743K	DO46396	OV	ICGC	RRRPLPRIH	DEG_APCC_DBOX_1	0.6126
p.A757G	DO32984	PACA	ICGC	RRRPLPRIH	DEG_APCC_DBOX_1	0.1111
p.R756W	DO218863	SKCA	ICGC	RRRPLPRIH	DEG_APCC_DBOX_1	0.1389
p.H751Y	DO233981	THCA	ICGC	RRRPLPRIH	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z5Q5	DNA polymerase nu	DEG_APCC_DBOX_1	741:749	RRRPLPRIH	APC,CDC20,FZR1	0.6834	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons