DegronMD - Q7Z5V6(PPP1R32)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q235H	TCGA-56-8305	LUSC	TCGA	KTHLHGD	LIG_APCC_ABBAyCdc20_2	245:251	Mutation rewiring degron network	0.0556
p.Q235H	DO223725	LUSC	ICGC	KTHLHGD	LIG_APCC_ABBAyCdc20_2	245:251	Mutation rewiring degron network	0.0556
p.L257F	TCGA-77-7141	LUSC	TCGA	KTHLHGD	LIG_APCC_ABBAyCdc20_2	245:251	Mutation rewiring degron network	0.1667
p.D241H	TCGA-A6-6782	COAD	TCGA	KTHLHGD	LIG_APCC_ABBAyCdc20_2	245:251	Mutation rewiring degron network	0.2222
p.D241H	DO10534	COAD	ICGC	KTHLHGD	LIG_APCC_ABBAyCdc20_2	245:251	Mutation rewiring degron network	0.2222
p.L248P	TCGA-CA-6717	COAD	TCGA	KTHLHGD	LIG_APCC_ABBAyCdc20_2	245:251	Mutation altering degron motif	0.7582
p.L248P	DO8264	COAD	ICGC	KTHLHGD	LIG_APCC_ABBAyCdc20_2	245:251	Mutation altering degron motif	0.7582
p.L248P	ACH-000998	Colon/Colorectal Cancer	CCLE	KTHLHGD	LIG_APCC_ABBAyCdc20_2	245:251	Mutation altering degron motif	0.7582
p.L248P	CW-2	large intestine	COSMIC	KTHLHGD	LIG_APCC_ABBAyCdc20_2	245:251	Mutation altering degron motif	0.7582
p.P244H	TCGA-FS-A1ZJ	SKCM	TCGA	KTHLHGD	LIG_APCC_ABBAyCdc20_2	245:251	Mutation rewiring degron network	0.3056
p.P244H	DO37956	SKCM	ICGC	KTHLHGD	LIG_APCC_ABBAyCdc20_2	245:251	Mutation rewiring degron network	0.3056
p.R249Q	DO49787	BLCA	ICGC	KTHLHGD	LIG_APCC_ABBAyCdc20_2	245:251	Mutation altering degron motif	0.7329
p.K245N	DO229031	LICA	ICGC	KTHLHGD	LIG_APCC_ABBAyCdc20_2	245:251	Mutation altering degron motif	0.6918
p.K245N	DO229045	LICA	ICGC	KTHLHGD	LIG_APCC_ABBAyCdc20_2	245:251	Mutation altering degron motif	0.6918
p.P260T	DO44802	LICA	ICGC	KTHLHGD	LIG_APCC_ABBAyCdc20_2	245:251	Mutation rewiring degron network	0.0833
p.Q235R	DO45267	LIRI	ICGC	KTHLHGD	LIG_APCC_ABBAyCdc20_2	245:251	Mutation rewiring degron network	0.0556
p.L237F	DO26450	LUSC	ICGC	KTHLHGD	LIG_APCC_ABBAyCdc20_2	245:251	Mutation rewiring degron network	0.1111
p.S236R	DO229234	THCA	ICGC	KTHLHGD	LIG_APCC_ABBAyCdc20_2	245:251	Mutation rewiring degron network	0.0833
p.P255S	SIDM00251	Gastric Carcinoma	GDSC	KTHLHGD	LIG_APCC_ABBAyCdc20_2	245:251	Mutation rewiring degron network	0.2222
p.P255S	ACH-000949	Gastric Cancer	CCLE	KTHLHGD	LIG_APCC_ABBAyCdc20_2	245:251	Mutation rewiring degron network	0.2222
p.R243W	HCT-15	large intestine	COSMIC	KTHLHGD	LIG_APCC_ABBAyCdc20_2	245:251	Mutation rewiring degron network	0.2778

Kaplan plot for PPP1R32 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPP1R32

UniProt ID: Q7Z5V6

Entrez ID: 220004

Protein name: Protein phosphatase 1 regulatory subunit 32

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPP1R32 in