DegronMD

Uniprot ID: Q7Z5V6

Source protein: Protein phosphatase 1 regulatory subunit 32

Source gene: PPP1R32

Class: LIG_APCC_ABBAyCdc20_2

Location: 245:251

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8884

ASA_SCORE: 69.9429

COIL: 0.7841

CONS_SCORE: 0.373

DSS_SCORE: 0.3842

HELIX: 0.1214

FCONS_SCORE: 0.8599

RIG_SCORE: 0.7323

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L248P	TCGA-CA-6717	COAD	TCGA	KTHLHGD	LIG_APCC_ABBAyCdc20_2	0.7582
p.L248P	DO8264	COAD	ICGC	KTHLHGD	LIG_APCC_ABBAyCdc20_2	0.7582
p.L248P	ACH-000998	Colon/Colorectal Cancer	CCLE	KTHLHGD	LIG_APCC_ABBAyCdc20_2	0.7582
p.L248P	CW-2	large_intestine	COSMIC	KTHLHGD	LIG_APCC_ABBAyCdc20_2	0.7582
p.R249Q	DO49787	BLCA	ICGC	KTHLHGD	LIG_APCC_ABBAyCdc20_2	0.7329
p.K245N	DO229031	LICA	ICGC	KTHLHGD	LIG_APCC_ABBAyCdc20_2	0.6918
p.K245N	DO229045	LICA	ICGC	KTHLHGD	LIG_APCC_ABBAyCdc20_2	0.6918
p.P244H	TCGA-FS-A1ZJ	SKCM	TCGA	KTHLHGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.P244H	DO37956	SKCM	ICGC	KTHLHGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R243W	HCT-15	large_intestine	COSMIC	KTHLHGD	LIG_APCC_ABBAyCdc20_2	0.2778
p.D241H	TCGA-A6-6782	COAD	TCGA	KTHLHGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.D241H	DO10534	COAD	ICGC	KTHLHGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.P255S	SIDM00251	Gastric Carcinoma	GDSC	KTHLHGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.P255S	ACH-000949	Gastric Cancer	CCLE	KTHLHGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.L257F	TCGA-77-7141	LUSC	TCGA	KTHLHGD	LIG_APCC_ABBAyCdc20_2	0.1667
p.L237F	DO26450	LUSC	ICGC	KTHLHGD	LIG_APCC_ABBAyCdc20_2	0.1111
p.P260T	DO44802	LICA	ICGC	KTHLHGD	LIG_APCC_ABBAyCdc20_2	0.0833
p.S236R	DO229234	THCA	ICGC	KTHLHGD	LIG_APCC_ABBAyCdc20_2	0.0833
p.Q235H	TCGA-56-8305	LUSC	TCGA	KTHLHGD	LIG_APCC_ABBAyCdc20_2	0.0556
p.Q235H	DO223725	LUSC	ICGC	KTHLHGD	LIG_APCC_ABBAyCdc20_2	0.0556
p.Q235R	DO45267	LIRI	ICGC	KTHLHGD	LIG_APCC_ABBAyCdc20_2	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z5V6	Protein phosphatase 1 regulatory subunit 32	LIG_APCC_ABBAyCdc20_2	245:251	KTHLHGD	APC,CDC20,FZR1	0.8884	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons