DegronMD - Q7Z601(GPR142)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E141K	TCGA-D3-A2JN	SKCM	TCGA	LLPTPHVS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.1389
p.E141K	TCGA-EE-A181	SKCM	TCGA	LLPTPHVS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.1389
p.E141K	DO37444	SKCM	ICGC	LLPTPHVS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.1389
p.E141K	DO47590	SKCM	ICGC	LLPTPHVS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.1389
p.V133I	TCGA-E3-A3E1	THCA	TCGA	LLPTPHVS	DEG_SCF_FBW7_1	127:134	Mutation altering degron motif	0.5965
p.V133I	DO38897	THCA	ICGC	LLPTPHVS	DEG_SCF_FBW7_1	127:134	Mutation altering degron motif	0.5965
p.G135W	TCGA-ET-A39R	THCA	TCGA	LLPTPHVS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.3056
p.G135W	DO39552	THCA	ICGC	LLPTPHVS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.3056
p.H132N	DO229010	COCA	ICGC	LLPTPHVS	DEG_SCF_FBW7_1	127:134	Mutation altering degron motif	0.6312
p.H132N	DO229013	COCA	ICGC	LLPTPHVS	DEG_SCF_FBW7_1	127:134	Mutation altering degron motif	0.6312
p.H132N	DO229016	COCA	ICGC	LLPTPHVS	DEG_SCF_FBW7_1	127:134	Mutation altering degron motif	0.6312
p.H132N	DO229003	COCA	ICGC	LLPTPHVS	DEG_SCF_FBW7_1	127:134	Mutation altering degron motif	0.6312
p.H132N	DO229005	COCA	ICGC	LLPTPHVS	DEG_SCF_FBW7_1	127:134	Mutation altering degron motif	0.6312
p.S142I	DO222465	ESCA	ICGC	LLPTPHVS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.1111
p.R124Q	DO233748	GACA	ICGC	LLPTPHVS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.25
p.R124Q	SIDM00773	Non-Cancerous	GDSC	LLPTPHVS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.25
p.R124Q	SIDM00529	Breast Carcinoma	GDSC	LLPTPHVS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.25
p.R124Q	SIDM01133	Other Solid Cancers	GDSC	LLPTPHVS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.25
p.R124Q	SIDM00774	Breast Carcinoma	GDSC	LLPTPHVS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.25
p.R124Q	SIDM01173	Rhabdomyosarcoma	GDSC	LLPTPHVS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.25
p.R124Q	SIDM00628	Breast Carcinoma	GDSC	LLPTPHVS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.25
p.R124Q	SIDM01686	Chronic Myelogenous Leukemia	GDSC	LLPTPHVS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.25
p.R124Q	SIDM01664	Prostate Carcinoma	GDSC	LLPTPHVS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.25
p.R124Q	SIDM01525	Acute Myeloid Leukemia	GDSC	LLPTPHVS	DEG_SCF_FBW7_1	127:134	Mutation rewiring degron network	0.25
p.P131L	DO50970	LICA	ICGC	LLPTPHVS	DEG_SCF_FBW7_1	127:134	Mutation altering degron motif	0.7582

Kaplan plot for GPR142 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GPR142

UniProt ID: Q7Z601

Entrez ID: 350383

Protein name: Probable G-protein coupled receptor 142 (G-protein coupled receptor PGR2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GPR142 in