DegronMD

Uniprot ID: Q7Z601

Source protein: Probable G-protein coupled receptor 142

Source gene: GPR142

Class: DEG_SCF_FBW7_1

Location: 127:134

E3 ligase: FBXW7

DEGRON score: 0.9846

ASA_SCORE: 52.975

COIL: 0.7571

CONS_SCORE: 0.2587

DSS_SCORE: 0.5302

HELIX: 0.0578

FCONS_SCORE: 1.0441

RIG_SCORE: 0.7054

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E141K	TCGA-D3-A2JN	SKCM	TCGA	LLPTPHVS	DEG_SCF_FBW7_1	0.1389
p.E141K	TCGA-EE-A181	SKCM	TCGA	LLPTPHVS	DEG_SCF_FBW7_1	0.1389
p.E141K	DO37444	SKCM	ICGC	LLPTPHVS	DEG_SCF_FBW7_1	0.1389
p.E141K	DO47590	SKCM	ICGC	LLPTPHVS	DEG_SCF_FBW7_1	0.1389
p.V133I	TCGA-E3-A3E1	THCA	TCGA	LLPTPHVS	DEG_SCF_FBW7_1	0.5965
p.V133I	DO38897	THCA	ICGC	LLPTPHVS	DEG_SCF_FBW7_1	0.5965
p.G135W	TCGA-ET-A39R	THCA	TCGA	LLPTPHVS	DEG_SCF_FBW7_1	0.3056
p.G135W	DO39552	THCA	ICGC	LLPTPHVS	DEG_SCF_FBW7_1	0.3056
p.H132N	DO229010	COCA	ICGC	LLPTPHVS	DEG_SCF_FBW7_1	0.6312
p.H132N	DO229013	COCA	ICGC	LLPTPHVS	DEG_SCF_FBW7_1	0.6312
p.H132N	DO229016	COCA	ICGC	LLPTPHVS	DEG_SCF_FBW7_1	0.6312
p.H132N	DO229003	COCA	ICGC	LLPTPHVS	DEG_SCF_FBW7_1	0.6312
p.H132N	DO229005	COCA	ICGC	LLPTPHVS	DEG_SCF_FBW7_1	0.6312
p.S142I	DO222465	ESCA	ICGC	LLPTPHVS	DEG_SCF_FBW7_1	0.1111
p.R124Q	DO233748	GACA	ICGC	LLPTPHVS	DEG_SCF_FBW7_1	0.25
p.R124Q	SIDM00773	Non-Cancerous	GDSC	LLPTPHVS	DEG_SCF_FBW7_1	0.25
p.R124Q	SIDM00529	Breast Carcinoma	GDSC	LLPTPHVS	DEG_SCF_FBW7_1	0.25
p.R124Q	SIDM01133	Other Solid Cancers	GDSC	LLPTPHVS	DEG_SCF_FBW7_1	0.25
p.R124Q	SIDM00774	Breast Carcinoma	GDSC	LLPTPHVS	DEG_SCF_FBW7_1	0.25
p.R124Q	SIDM01173	Rhabdomyosarcoma	GDSC	LLPTPHVS	DEG_SCF_FBW7_1	0.25
p.R124Q	SIDM00628	Breast Carcinoma	GDSC	LLPTPHVS	DEG_SCF_FBW7_1	0.25
p.R124Q	SIDM01686	Chronic Myelogenous Leukemia	GDSC	LLPTPHVS	DEG_SCF_FBW7_1	0.25
p.R124Q	SIDM01664	Prostate Carcinoma	GDSC	LLPTPHVS	DEG_SCF_FBW7_1	0.25
p.R124Q	SIDM01525	Acute Myeloid Leukemia	GDSC	LLPTPHVS	DEG_SCF_FBW7_1	0.25
p.P131L	DO50970	LICA	ICGC	LLPTPHVS	DEG_SCF_FBW7_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z601	Probable G-protein coupled receptor 142	DEG_SCF_FBW7_1	127:134	LLPTPHVS	FBXW7	0.9846	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons