DegronMD - Q7Z628(NET1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R130T	TCGA-18-3410	LUSC	TCGA	SSRSTVPTP	DEG_COP1_1	139:147	Mutation rewiring degron network	0.0833
p.R130T	DO26456	LUSC	ICGC	SSRSTVPTP	DEG_COP1_1	139:147	Mutation rewiring degron network	0.0833
p.A135T	TCGA-BT-A42F	BLCA	TCGA	SSRSTVPTP	DEG_COP1_1	139:147	Mutation rewiring degron network	0.2222
p.A135T	DO49726	BLCA	ICGC	SSRSTVPTP	DEG_COP1_1	139:147	Mutation rewiring degron network	0.2222
p.S131F	TCGA-FS-A1ZD	SKCM	TCGA	SSRSTVPTP	DEG_COP1_1	139:147	Mutation rewiring degron network	0.1111
p.S131F	DO37627	SKCM	ICGC	SSRSTVPTP	DEG_COP1_1	139:147	Mutation rewiring degron network	0.1111
p.A148T	DO230309	COCA	ICGC	SSRSTVPTP	DEG_COP1_1	139:147	Mutation rewiring degron network	0.3056
p.A133S	DO233896	GACA	ICGC	SSRSTVPTP	DEG_COP1_1	139:147	Mutation rewiring degron network	0.1667
p.Q136H	DO229026	LICA	ICGC	SSRSTVPTP	DEG_COP1_1	139:147	Mutation rewiring degron network	0.25
p.W156C	DO229026	LICA	ICGC	SSRSTVPTP	DEG_COP1_1	139:147	Mutation rewiring degron network	0.0833
p.R130I	DO229009	LICA	ICGC	SSRSTVPTP	DEG_COP1_1	139:147	Mutation rewiring degron network	0.0833
p.K137R	SIDM00498	Colorectal Carcinoma	GDSC	SSRSTVPTP	DEG_COP1_1	139:147	Mutation blocking ubiquitination signal	0.7222
p.K137R	SNU-C5	large intestine	COSMIC	SSRSTVPTP	DEG_COP1_1	139:147	Mutation blocking ubiquitination signal	0.7222
p.S153G	SIDM01454	Kidney Carcinoma	GDSC	SSRSTVPTP	DEG_COP1_1	139:147	Mutation rewiring degron network	0.1667
p.D148N	ACH-000374	Breast Cancer	CCLE	SSRSTVPTP	DEG_COP1_1	139:147	Mutation rewiring degron network	0.3056
p.D148N	HCC1143	breast	COSMIC	SSRSTVPTP	DEG_COP1_1	139:147	Mutation rewiring degron network	0.3056
p.G131C	ACH-000961	Endometrial/Uterine Cancer	CCLE	SSRSTVPTP	DEG_COP1_1	139:147	Mutation rewiring degron network	0.1111

Kaplan plot for NET1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NET1

UniProt ID: Q7Z628

Entrez ID: 10276

Protein name: Neuroepithelial cell-transforming gene 1 protein (Proto-oncogene p65 Net1) (Rho guanine nucleotide exchange factor 8)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NET1 in