DegronMD

Uniprot ID: Q7Z628

Source protein: Neuroepithelial cell-transforming gene 1 protein

Source gene: NET1

Class: DEG_COP1_1

Location: 139:147

E3 ligase: COP1

DEGRON score: 0.9809

ASA_SCORE: 89.3

COIL: 0.9137

CONS_SCORE: 0.5485

DSS_SCORE: 0.5927

HELIX: 0.051

FCONS_SCORE: 1.1207

RIG_SCORE: 0.6463

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R130T	TCGA-18-3410	LUSC	TCGA	SSRSTVPTP	DEG_COP1_1	0.0833
p.R130T	DO26456	LUSC	ICGC	SSRSTVPTP	DEG_COP1_1	0.0833
p.A135T	TCGA-BT-A42F	BLCA	TCGA	SSRSTVPTP	DEG_COP1_1	0.2222
p.A135T	DO49726	BLCA	ICGC	SSRSTVPTP	DEG_COP1_1	0.2222
p.S131F	TCGA-FS-A1ZD	SKCM	TCGA	SSRSTVPTP	DEG_COP1_1	0.1111
p.S131F	DO37627	SKCM	ICGC	SSRSTVPTP	DEG_COP1_1	0.1111
p.A148T	DO230309	COCA	ICGC	SSRSTVPTP	DEG_COP1_1	0.3056
p.A133S	DO233896	GACA	ICGC	SSRSTVPTP	DEG_COP1_1	0.1667
p.Q136H	DO229026	LICA	ICGC	SSRSTVPTP	DEG_COP1_1	0.25
p.W156C	DO229026	LICA	ICGC	SSRSTVPTP	DEG_COP1_1	0.0833
p.R130I	DO229009	LICA	ICGC	SSRSTVPTP	DEG_COP1_1	0.0833
p.K137R	SIDM00498	Colorectal Carcinoma	GDSC	SSRSTVPTP	DEG_COP1_1	0.7222
p.K137R	SNU-C5	large_intestine	COSMIC	SSRSTVPTP	DEG_COP1_1	0.7222
p.S153G	SIDM01454	Kidney Carcinoma	GDSC	SSRSTVPTP	DEG_COP1_1	0.1667
p.D148N	ACH-000374	Breast Cancer	CCLE	SSRSTVPTP	DEG_COP1_1	0.3056
p.D148N	HCC1143	breast	COSMIC	SSRSTVPTP	DEG_COP1_1	0.3056
p.G131C	ACH-000961	Endometrial/Uterine Cancer	CCLE	SSRSTVPTP	DEG_COP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z628	Neuroepithelial cell-transforming gene 1 protein	DEG_COP1_1	139:147	SSRSTVPTP	COP1	0.9809	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons