DegronMD - Q7Z6J4(FGD2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T67R	TCGA-66-2754	LUSC	TCGA	SRRYLNSLK	DEG_APCC_DBOX_1	69:77	Mutation blocking phosphorylation signal	0.7222
p.T67R	DO27612	LUSC	ICGC	SRRYLNSLK	DEG_APCC_DBOX_1	69:77	Mutation blocking phosphorylation signal	0.7222
p.V68A	TCGA-KQ-A41R	BLCA	TCGA	SRRYLNSLK	DEG_APCC_DBOX_1	69:77	Mutation rewiring degron network	0.3056
p.V68A	DO223592	BLCA	ICGC	SRRYLNSLK	DEG_APCC_DBOX_1	69:77	Mutation rewiring degron network	0.3056
p.T67P	DO225346	BRCA	ICGC	SRRYLNSLK	DEG_APCC_DBOX_1	69:77	Mutation blocking phosphorylation signal	0.7222
p.G62E	DO222662	MELA	ICGC	SRRYLNSLK	DEG_APCC_DBOX_1	69:77	Mutation rewiring degron network	0.1389
p.L80P	SIDM00789	Colorectal Carcinoma	GDSC	SRRYLNSLK	DEG_APCC_DBOX_1	69:77	Mutation rewiring degron network	0.25
p.L80P	ACH-000997	Colon/Colorectal Cancer	CCLE	SRRYLNSLK	DEG_APCC_DBOX_1	69:77	Mutation rewiring degron network	0.25
p.L80P	HCT-15	large intestine	COSMIC	SRRYLNSLK	DEG_APCC_DBOX_1	69:77	Mutation rewiring degron network	0.25
p.S69T	SIDM00950	Pancreatic Carcinoma	GDSC	SRRYLNSLK	DEG_APCC_DBOX_1	69:77	Mutation altering degron motif	0.7116
p.S69T	SIDM00042	Pancreatic Carcinoma	GDSC	SRRYLNSLK	DEG_APCC_DBOX_1	69:77	Mutation altering degron motif	0.7116
p.S69T	SIDM01504	Small Cell Lung Carcinoma	GDSC	SRRYLNSLK	DEG_APCC_DBOX_1	69:77	Mutation altering degron motif	0.7116
p.V61M	SIDM00948	Burkitt's Lymphoma	GDSC	SRRYLNSLK	DEG_APCC_DBOX_1	69:77	Mutation rewiring degron network	0.1111
p.V61M	SIDM00309	Mesothelioma	GDSC	SRRYLNSLK	DEG_APCC_DBOX_1	69:77	Mutation rewiring degron network	0.1111
p.V61M	SIDM00808	Burkitt's Lymphoma	GDSC	SRRYLNSLK	DEG_APCC_DBOX_1	69:77	Mutation rewiring degron network	0.1111
p.S75F	ACH-001034	Bone Cancer	CCLE	SRRYLNSLK	DEG_APCC_DBOX_1	69:77	Mutation altering degron motif	0.7982

Kaplan plot for FGD2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FGD2

UniProt ID: Q7Z6J4

Entrez ID: 221472

Protein name: FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FGD2 in