DegronMD

Uniprot ID: Q7Z6J4

Source protein: FYVE, RhoGEF and PH domain-containing protein 2

Source gene: FGD2

Class: DEG_APCC_DBOX_1

Location: 69:77

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.704

ASA_SCORE: 98.2889

COIL: 0.5777

CONS_SCORE: 0.3225

DSS_SCORE: 0.4763

HELIX: 0.3926

FCONS_SCORE: 0.8993

RIG_SCORE: 0.778

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T67R	TCGA-66-2754	LUSC	TCGA	SRRYLNSLK	DEG_APCC_DBOX_1	0.7222
p.T67R	DO27612	LUSC	ICGC	SRRYLNSLK	DEG_APCC_DBOX_1	0.7222
p.V68A	TCGA-KQ-A41R	BLCA	TCGA	SRRYLNSLK	DEG_APCC_DBOX_1	0.3056
p.V68A	DO223592	BLCA	ICGC	SRRYLNSLK	DEG_APCC_DBOX_1	0.3056
p.T67P	DO225346	BRCA	ICGC	SRRYLNSLK	DEG_APCC_DBOX_1	0.7222
p.G62E	DO222662	MELA	ICGC	SRRYLNSLK	DEG_APCC_DBOX_1	0.1389
p.L80P	SIDM00789	Colorectal Carcinoma	GDSC	SRRYLNSLK	DEG_APCC_DBOX_1	0.25
p.L80P	ACH-000997	Colon/Colorectal Cancer	CCLE	SRRYLNSLK	DEG_APCC_DBOX_1	0.25
p.L80P	HCT-15	large_intestine	COSMIC	SRRYLNSLK	DEG_APCC_DBOX_1	0.25
p.S69T	SIDM00950	Pancreatic Carcinoma	GDSC	SRRYLNSLK	DEG_APCC_DBOX_1	0.7116
p.S69T	SIDM00042	Pancreatic Carcinoma	GDSC	SRRYLNSLK	DEG_APCC_DBOX_1	0.7116
p.S69T	SIDM01504	Small Cell Lung Carcinoma	GDSC	SRRYLNSLK	DEG_APCC_DBOX_1	0.7116
p.V61M	SIDM00948	Burkitt's Lymphoma	GDSC	SRRYLNSLK	DEG_APCC_DBOX_1	0.1111
p.V61M	SIDM00309	Mesothelioma	GDSC	SRRYLNSLK	DEG_APCC_DBOX_1	0.1111
p.V61M	SIDM00808	Burkitt's Lymphoma	GDSC	SRRYLNSLK	DEG_APCC_DBOX_1	0.1111
p.S75F	ACH-001034	Bone Cancer	CCLE	SRRYLNSLK	DEG_APCC_DBOX_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z6J4	FYVE, RhoGEF and PH domain-containing protein 2	DEG_APCC_DBOX_1	69:77	SRRYLNSLK	APC,CDC20,FZR1	0.704	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons