DegronMD - Q7Z7H5(TMED4)

TMED4

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K65Q	TCGA-B1-A657	KIRP	TCGA	LGMHVE	LIG_APCC_ABBA_1	75:80	Mutation blocking ubiquitination signal	0.5
p.K65Q	DO51552	KIRP	ICGC	LGMHVE	LIG_APCC_ABBA_1	75:80	Mutation blocking ubiquitination signal	0.5
p.P84L	TCGA-FR-A726	SKCM	TCGA	LGMHVE	LIG_APCC_ABBA_1	75:80	Mutation rewiring degron network	0.2222
p.P84L	DO48665	SKCM	ICGC	LGMHVE	LIG_APCC_ABBA_1	75:80	Mutation rewiring degron network	0.2222
p.K65N	TCGA-HF-A5NB	STAD	TCGA	LGMHVE	LIG_APCC_ABBA_1	75:80	Mutation blocking ubiquitination signal	0.5
p.K65N	DO50127	STAD	ICGC	LGMHVE	LIG_APCC_ABBA_1	75:80	Mutation blocking ubiquitination signal	0.5
p.L90M	DO229045	LICA	ICGC	LGMHVE	LIG_APCC_ABBA_1	75:80	Mutation rewiring degron network	0.0556
p.K82T	SIDM01588	Endometrial Carcinoma	GDSC	LGMHVE	LIG_APCC_ABBA_1	75:80	Mutation blocking ubiquitination signal	0.7222
p.K82T	ACH-000993	Endometrial/Uterine Cancer	CCLE	LGMHVE	LIG_APCC_ABBA_1	75:80	Mutation blocking ubiquitination signal	0.7222
p.G86D	ACH-001610	Brain Cancer	CCLE	LGMHVE	LIG_APCC_ABBA_1	75:80	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc