DegronMD

Uniprot ID: Q7Z7H5

Source protein: Transmembrane emp24 domain-containing protein 4

Source gene: TMED4

Class: LIG_APCC_ABBA_1

Location: 75:80

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6087

ASA_SCORE: 24.7833

COIL: 0.1097

CONS_SCORE: 0.5153

DSS_SCORE: 0.4397

HELIX: 0.0075

FCONS_SCORE: 1.2267

RIG_SCORE: 0.734

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K65Q	TCGA-B1-A657	KIRP	TCGA	LGMHVE	LIG_APCC_ABBA_1	0.5
p.K65Q	DO51552	KIRP	ICGC	LGMHVE	LIG_APCC_ABBA_1	0.5
p.P84L	TCGA-FR-A726	SKCM	TCGA	LGMHVE	LIG_APCC_ABBA_1	0.2222
p.P84L	DO48665	SKCM	ICGC	LGMHVE	LIG_APCC_ABBA_1	0.2222
p.K65N	TCGA-HF-A5NB	STAD	TCGA	LGMHVE	LIG_APCC_ABBA_1	0.5
p.K65N	DO50127	STAD	ICGC	LGMHVE	LIG_APCC_ABBA_1	0.5
p.L90M	DO229045	LICA	ICGC	LGMHVE	LIG_APCC_ABBA_1	0.0556
p.K82T	SIDM01588	Endometrial Carcinoma	GDSC	LGMHVE	LIG_APCC_ABBA_1	0.7222
p.K82T	ACH-000993	Endometrial/Uterine Cancer	CCLE	LGMHVE	LIG_APCC_ABBA_1	0.7222
p.G86D	ACH-001610	Brain Cancer	CCLE	LGMHVE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z7H5	Transmembrane emp24 domain-containing protein 4	LIG_APCC_ABBA_1	75:80	LGMHVE	APC,CDC20,FZR1	0.6087	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons