DegronMD - Q86SJ2(AMIGO2)

AMIGO2

UniProt ID: Q86SJ2

Entrez ID: 347902

Protein name: Amphoterin-induced protein 2 (AMIGO-2) (Alivin-1) (Differentially expressed in gastric adenocarcinomas) (DEGA)

External links: UniprotKB HGNC RefSeq COSMIC

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A455T	TCGA-43-8118	LUSC	TCGA	KRVVFLE	LIG_APCC_ABBAyCdc20_2	464:470	Mutation rewiring degron network	0.0833
p.A455T	DO223045	ESCA	ICGC	KRVVFLE	LIG_APCC_ABBAyCdc20_2	464:470	Mutation rewiring degron network	0.0833
p.A455T	DO45471	LUSC	ICGC	KRVVFLE	LIG_APCC_ABBAyCdc20_2	464:470	Mutation rewiring degron network	0.0833
p.A477T	TCGA-AN-A0FJ	BRCA	TCGA	KRVVFLE	LIG_APCC_ABBAyCdc20_2	464:470	Mutation rewiring degron network	0.1389
p.A477T	DO5060	BRCA	ICGC	KRVVFLE	LIG_APCC_ABBAyCdc20_2	464:470	Mutation rewiring degron network	0.1389
p.R458Q	TCGA-BR-8368	STAD	TCGA	KRVVFLE	LIG_APCC_ABBAyCdc20_2	464:470	Mutation rewiring degron network	0.1667
p.R458Q	DO47981	STAD	ICGC	KRVVFLE	LIG_APCC_ABBAyCdc20_2	464:470	Mutation rewiring degron network	0.1667
p.G478E	TCGA-BS-A0UF	UCEC	TCGA	KRVVFLE	LIG_APCC_ABBAyCdc20_2	464:470	Mutation rewiring degron network	0.1111
p.G478E	DO41488	UCEC	ICGC	KRVVFLE	LIG_APCC_ABBAyCdc20_2	464:470	Mutation rewiring degron network	0.1111
p.S454F	TCGA-CC-A7IJ	LIHC	TCGA	KRVVFLE	LIG_APCC_ABBAyCdc20_2	464:470	Mutation rewiring degron network	0.0556
p.S454F	DO52183	LIHC	ICGC	KRVVFLE	LIG_APCC_ABBAyCdc20_2	464:470	Mutation rewiring degron network	0.0556
p.S454F	SIDM02066	Colorectal Carcinoma	GDSC	KRVVFLE	LIG_APCC_ABBAyCdc20_2	464:470	Mutation rewiring degron network	0.0556
p.A455D	TCGA-DX-A6YV	SARC	TCGA	KRVVFLE	LIG_APCC_ABBAyCdc20_2	464:470	Mutation rewiring degron network	0.0833
p.A455D	DO220011	SARC	ICGC	KRVVFLE	LIG_APCC_ABBAyCdc20_2	464:470	Mutation rewiring degron network	0.0833
p.R465I	TCGA-EE-A2GN	SKCM	TCGA	KRVVFLE	LIG_APCC_ABBAyCdc20_2	464:470	Mutation altering degron motif	0.6991
p.R465I	DO37896	SKCM	ICGC	KRVVFLE	LIG_APCC_ABBAyCdc20_2	464:470	Mutation altering degron motif	0.6991
p.F468S	TCGA-ER-A19J	SKCM	TCGA	KRVVFLE	LIG_APCC_ABBAyCdc20_2	464:470	Mutation altering degron motif	0.7982
p.F468S	DO37426	SKCM	ICGC	KRVVFLE	LIG_APCC_ABBAyCdc20_2	464:470	Mutation altering degron motif	0.7982
p.R465K	TCGA-FR-A726	SKCM	TCGA	KRVVFLE	LIG_APCC_ABBAyCdc20_2	464:470	Mutation altering degron motif	0.6126
p.R465K	DO48665	SKCM	ICGC	KRVVFLE	LIG_APCC_ABBAyCdc20_2	464:470	Mutation altering degron motif	0.6126
p.R465S	TCGA-P5-A5EU	LGG	TCGA	KRVVFLE	LIG_APCC_ABBAyCdc20_2	464:470	Mutation altering degron motif	0.6316
p.R465S	DO50159	LGG	ICGC	KRVVFLE	LIG_APCC_ABBAyCdc20_2	464:470	Mutation altering degron motif	0.6316
p.G478V	SIDM00195	Ewing's Sarcoma	GDSC	KRVVFLE	LIG_APCC_ABBAyCdc20_2	464:470	Mutation rewiring degron network	0.1111
p.G478V	ACH-002117	Bone Cancer	CCLE	KRVVFLE	LIG_APCC_ABBAyCdc20_2	464:470	Mutation rewiring degron network	0.1111
p.G478V	EW-24	bone	COSMIC	KRVVFLE	LIG_APCC_ABBAyCdc20_2	464:470	Mutation rewiring degron network	0.1111

Kaplan plot for AMIGO2 in

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*NOTE: the Kaplan plots were collected from OncoLnc