DegronMD

Uniprot ID: Q86SJ2

Source protein: Amphoterin-induced protein 2

Source gene: AMIGO2

Class: LIG_APCC_ABBAyCdc20_2

Location: 464:470

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8335

ASA_SCORE: 60.6714

COIL: 0.6341

CONS_SCORE: 0.7252

DSS_SCORE: 0.4023

HELIX: 0.0497

FCONS_SCORE: 1.2565

RIG_SCORE: 0.8206

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A455T	TCGA-43-8118	LUSC	TCGA	KRVVFLE	LIG_APCC_ABBAyCdc20_2	0.0833
p.A455T	DO223045	ESCA	ICGC	KRVVFLE	LIG_APCC_ABBAyCdc20_2	0.0833
p.A455T	DO45471	LUSC	ICGC	KRVVFLE	LIG_APCC_ABBAyCdc20_2	0.0833
p.A477T	TCGA-AN-A0FJ	BRCA	TCGA	KRVVFLE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A477T	DO5060	BRCA	ICGC	KRVVFLE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R458Q	TCGA-BR-8368	STAD	TCGA	KRVVFLE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R458Q	DO47981	STAD	ICGC	KRVVFLE	LIG_APCC_ABBAyCdc20_2	0.1667
p.G478E	TCGA-BS-A0UF	UCEC	TCGA	KRVVFLE	LIG_APCC_ABBAyCdc20_2	0.1111
p.G478E	DO41488	UCEC	ICGC	KRVVFLE	LIG_APCC_ABBAyCdc20_2	0.1111
p.S454F	TCGA-CC-A7IJ	LIHC	TCGA	KRVVFLE	LIG_APCC_ABBAyCdc20_2	0.0556
p.S454F	DO52183	LIHC	ICGC	KRVVFLE	LIG_APCC_ABBAyCdc20_2	0.0556
p.S454F	SIDM02066	Colorectal Carcinoma	GDSC	KRVVFLE	LIG_APCC_ABBAyCdc20_2	0.0556
p.A455D	TCGA-DX-A6YV	SARC	TCGA	KRVVFLE	LIG_APCC_ABBAyCdc20_2	0.0833
p.A455D	DO220011	SARC	ICGC	KRVVFLE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R465I	TCGA-EE-A2GN	SKCM	TCGA	KRVVFLE	LIG_APCC_ABBAyCdc20_2	0.6991
p.R465I	DO37896	SKCM	ICGC	KRVVFLE	LIG_APCC_ABBAyCdc20_2	0.6991
p.F468S	TCGA-ER-A19J	SKCM	TCGA	KRVVFLE	LIG_APCC_ABBAyCdc20_2	0.7982
p.F468S	DO37426	SKCM	ICGC	KRVVFLE	LIG_APCC_ABBAyCdc20_2	0.7982
p.R465K	TCGA-FR-A726	SKCM	TCGA	KRVVFLE	LIG_APCC_ABBAyCdc20_2	0.6126
p.R465K	DO48665	SKCM	ICGC	KRVVFLE	LIG_APCC_ABBAyCdc20_2	0.6126
p.R465S	TCGA-P5-A5EU	LGG	TCGA	KRVVFLE	LIG_APCC_ABBAyCdc20_2	0.6316
p.R465S	DO50159	LGG	ICGC	KRVVFLE	LIG_APCC_ABBAyCdc20_2	0.6316
p.G478V	SIDM00195	Ewing's Sarcoma	GDSC	KRVVFLE	LIG_APCC_ABBAyCdc20_2	0.1111
p.G478V	ACH-002117	Bone Cancer	CCLE	KRVVFLE	LIG_APCC_ABBAyCdc20_2	0.1111
p.G478V	EW-24	bone	COSMIC	KRVVFLE	LIG_APCC_ABBAyCdc20_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86SJ2	Amphoterin-induced protein 2	LIG_APCC_ABBAyCdc20_2	464:470	KRVVFLE	APC,CDC20,FZR1	0.8335	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KRVVFLE

Degron related mutations and impact score

Drug responses associated with AMIGO2 mutations

All proteins holding degron of KRVVFLE