DegronMD - Q86SP6(GPR149)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P650S	TCGA-AA-3811	COAD	TCGA	RKENR	DEG_APCC_KENBOX_2	656:660	Mutation rewiring degron network	0.1667
p.P650S	DO7962	COAD	ICGC	RKENR	DEG_APCC_KENBOX_2	656:660	Mutation rewiring degron network	0.1667
p.P650S	DO229050	LICA	ICGC	RKENR	DEG_APCC_KENBOX_2	656:660	Mutation rewiring degron network	0.1667
p.L666P	TCGA-AX-A0J0	UCEC	TCGA	RKENR	DEG_APCC_KENBOX_2	656:660	Mutation rewiring degron network	0.1667
p.L666P	DO41133	UCEC	ICGC	RKENR	DEG_APCC_KENBOX_2	656:660	Mutation rewiring degron network	0.1667
p.S649Y	TCGA-B5-A1MR	UCEC	TCGA	RKENR	DEG_APCC_KENBOX_2	656:660	Mutation rewiring degron network	0.1389
p.S649Y	DO41758	UCEC	ICGC	RKENR	DEG_APCC_KENBOX_2	656:660	Mutation rewiring degron network	0.1389
p.R653H	TCGA-BH-A0EI	BRCA	TCGA	RKENR	DEG_APCC_KENBOX_2	656:660	Mutation rewiring degron network	0.25
p.R653H	DO2407	BRCA	ICGC	RKENR	DEG_APCC_KENBOX_2	656:660	Mutation rewiring degron network	0.25
p.A670T	TCGA-BR-4184	STAD	TCGA	RKENR	DEG_APCC_KENBOX_2	656:660	Mutation rewiring degron network	0.0556
p.A670T	DO38328	STAD	ICGC	RKENR	DEG_APCC_KENBOX_2	656:660	Mutation rewiring degron network	0.0556
p.R660I	DO222798	COCA	ICGC	RKENR	DEG_APCC_KENBOX_2	656:660	Mutation altering degron motif	0.6991
p.L652P	DO228560	LICA	ICGC	RKENR	DEG_APCC_KENBOX_2	656:660	Mutation rewiring degron network	0.2222
p.T669K	DO229041	LICA	ICGC	RKENR	DEG_APCC_KENBOX_2	656:660	Mutation rewiring degron network	0.0833
p.N659K	SIDM00636	Non-Cancerous	GDSC	RKENR	DEG_APCC_KENBOX_2	656:660	Mutation altering degron motif	0.6918
p.N659K	ACH-002270	Non-Cancerous	CCLE	RKENR	DEG_APCC_KENBOX_2	656:660	Mutation altering degron motif	0.6918
p.N659K	MC-CAR	haematopoietic and lymphoid tissue	COSMIC	RKENR	DEG_APCC_KENBOX_2	656:660	Mutation altering degron motif	0.6918

Kaplan plot for GPR149 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GPR149

UniProt ID: Q86SP6

Entrez ID: 344758

Protein name: Probable G-protein coupled receptor 149 (G-protein coupled receptor PGR10)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GPR149 in