DegronMD

Uniprot ID: Q86SP6

Source protein: Probable G-protein coupled receptor 149

Source gene: GPR149

Class: DEG_APCC_KENBOX_2

Location: 656:660

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5414

ASA_SCORE: 112.68

COIL: 0.6806

CONS_SCORE: 0.8117

DSS_SCORE: 0.3433

HELIX: 0.045

FCONS_SCORE: 0.9941

RIG_SCORE: 0.752

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P650S	TCGA-AA-3811	COAD	TCGA	RKENR	DEG_APCC_KENBOX_2	0.1667
p.P650S	DO7962	COAD	ICGC	RKENR	DEG_APCC_KENBOX_2	0.1667
p.P650S	DO229050	LICA	ICGC	RKENR	DEG_APCC_KENBOX_2	0.1667
p.L666P	TCGA-AX-A0J0	UCEC	TCGA	RKENR	DEG_APCC_KENBOX_2	0.1667
p.L666P	DO41133	UCEC	ICGC	RKENR	DEG_APCC_KENBOX_2	0.1667
p.S649Y	TCGA-B5-A1MR	UCEC	TCGA	RKENR	DEG_APCC_KENBOX_2	0.1389
p.S649Y	DO41758	UCEC	ICGC	RKENR	DEG_APCC_KENBOX_2	0.1389
p.R653H	TCGA-BH-A0EI	BRCA	TCGA	RKENR	DEG_APCC_KENBOX_2	0.25
p.R653H	DO2407	BRCA	ICGC	RKENR	DEG_APCC_KENBOX_2	0.25
p.A670T	TCGA-BR-4184	STAD	TCGA	RKENR	DEG_APCC_KENBOX_2	0.0556
p.A670T	DO38328	STAD	ICGC	RKENR	DEG_APCC_KENBOX_2	0.0556
p.R660I	DO222798	COCA	ICGC	RKENR	DEG_APCC_KENBOX_2	0.6991
p.L652P	DO228560	LICA	ICGC	RKENR	DEG_APCC_KENBOX_2	0.2222
p.T669K	DO229041	LICA	ICGC	RKENR	DEG_APCC_KENBOX_2	0.0833
p.N659K	SIDM00636	Non-Cancerous	GDSC	RKENR	DEG_APCC_KENBOX_2	0.6918
p.N659K	ACH-002270	Non-Cancerous	CCLE	RKENR	DEG_APCC_KENBOX_2	0.6918
p.N659K	MC-CAR	haematopoietic_and_lymphoid_tissue	COSMIC	RKENR	DEG_APCC_KENBOX_2	0.6918

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86SP6	Probable G-protein coupled receptor 149	DEG_APCC_KENBOX_2	656:660	RKENR	APC,CDC20,FZR1	0.5414	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons