DegronMD - Q86SS6(SYT9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N413S	TCGA-56-8622	LUSC	TCGA	KRNTLNPVY	DEG_APCC_DBOX_1	411:419	Mutation altering degron motif	0.5958
p.N413S	DO45449	LUSC	ICGC	KRNTLNPVY	DEG_APCC_DBOX_1	411:419	Mutation altering degron motif	0.5958
p.R402Q	TCGA-AQ-A0Y5	BRCA	TCGA	KRNTLNPVY	DEG_APCC_DBOX_1	411:419	Mutation rewiring degron network	0.0833
p.R402Q	DO5738	BRCA	ICGC	KRNTLNPVY	DEG_APCC_DBOX_1	411:419	Mutation rewiring degron network	0.0833
p.K404R	TCGA-BR-8589	STAD	TCGA	KRNTLNPVY	DEG_APCC_DBOX_1	411:419	Mutation substituting flanking lysine	0.25
p.K404R	DO47813	STAD	ICGC	KRNTLNPVY	DEG_APCC_DBOX_1	411:419	Mutation substituting flanking lysine	0.25
p.P429L	TCGA-EE-A29V	SKCM	TCGA	KRNTLNPVY	DEG_APCC_DBOX_1	411:419	Mutation rewiring degron network	0.0556
p.P429L	DO38006	SKCM	ICGC	KRNTLNPVY	DEG_APCC_DBOX_1	411:419	Mutation rewiring degron network	0.0556
p.K411N	TCGA-EK-A3GK	CESC	TCGA	KRNTLNPVY	DEG_APCC_DBOX_1	411:419	Mutation altering degron motif	0.5806
p.K411N	DO49964	CESC	ICGC	KRNTLNPVY	DEG_APCC_DBOX_1	411:419	Mutation altering degron motif	0.5806
p.P428S	TCGA-FW-A3R5	SKCM	TCGA	KRNTLNPVY	DEG_APCC_DBOX_1	411:419	Mutation rewiring degron network	0.0833
p.P428S	DO37406	SKCM	ICGC	KRNTLNPVY	DEG_APCC_DBOX_1	411:419	Mutation rewiring degron network	0.0833
p.E421K	TCGA-IQ-7632	HNSC	TCGA	KRNTLNPVY	DEG_APCC_DBOX_1	411:419	Mutation rewiring degron network	0.2778
p.E421K	DO14353	HNSC	ICGC	KRNTLNPVY	DEG_APCC_DBOX_1	411:419	Mutation rewiring degron network	0.2778
p.T414N	DO222762	COCA	ICGC	KRNTLNPVY	DEG_APCC_DBOX_1	411:419	Mutation altering degron motif	0.5944
p.V427F	DO228900	LICA	ICGC	KRNTLNPVY	DEG_APCC_DBOX_1	411:419	Mutation rewiring degron network	0.1111
p.V424F	DO228985	LICA	ICGC	KRNTLNPVY	DEG_APCC_DBOX_1	411:419	Mutation rewiring degron network	0.1944
p.L415F	DO229045	LICA	ICGC	KRNTLNPVY	DEG_APCC_DBOX_1	411:419	Mutation altering degron motif	0.6981
p.N420H	DO218847	SKCA	ICGC	KRNTLNPVY	DEG_APCC_DBOX_1	411:419	Mutation rewiring degron network	0.3056
p.R406G	SIDM01282	Colorectal Carcinoma	GDSC	KRNTLNPVY	DEG_APCC_DBOX_1	411:419	Mutation rewiring degron network	0.1944
p.Y419D	SIDM01245	T-Lymphoblastic Leukemia	GDSC	KRNTLNPVY	DEG_APCC_DBOX_1	411:419	Mutation altering degron motif	0.6214
p.Y419D	BE-13	haematopoietic and lymphoid tissue	COSMIC	KRNTLNPVY	DEG_APCC_DBOX_1	411:419	Mutation altering degron motif	0.6214
p.T410I	ACH-001611	Brain Cancer	CCLE	KRNTLNPVY	DEG_APCC_DBOX_1	411:419	Mutation rewiring degron network	0.3056

Kaplan plot for SYT9 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SYT9

UniProt ID: Q86SS6

Entrez ID: 143425

Protein name: Synaptotagmin-9 (Synaptotagmin IX) (SytIX)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SYT9 in