DegronMD

Uniprot ID: Q86SS6

Source protein: Synaptotagmin-9

Source gene: SYT9

Class: DEG_APCC_DBOX_1

Location: 411:419

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5519

ASA_SCORE: 87.4889

COIL: 0.7819

CONS_SCORE: 0.4161

DSS_SCORE: 0.3459

HELIX: 0.0127

FCONS_SCORE: 1.2188

RIG_SCORE: 0.769

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N413S	TCGA-56-8622	LUSC	TCGA	KRNTLNPVY	DEG_APCC_DBOX_1	0.5958
p.N413S	DO45449	LUSC	ICGC	KRNTLNPVY	DEG_APCC_DBOX_1	0.5958
p.R402Q	TCGA-AQ-A0Y5	BRCA	TCGA	KRNTLNPVY	DEG_APCC_DBOX_1	0.0833
p.R402Q	DO5738	BRCA	ICGC	KRNTLNPVY	DEG_APCC_DBOX_1	0.0833
p.K404R	TCGA-BR-8589	STAD	TCGA	KRNTLNPVY	DEG_APCC_DBOX_1	0.25
p.K404R	DO47813	STAD	ICGC	KRNTLNPVY	DEG_APCC_DBOX_1	0.25
p.P429L	TCGA-EE-A29V	SKCM	TCGA	KRNTLNPVY	DEG_APCC_DBOX_1	0.0556
p.P429L	DO38006	SKCM	ICGC	KRNTLNPVY	DEG_APCC_DBOX_1	0.0556
p.K411N	TCGA-EK-A3GK	CESC	TCGA	KRNTLNPVY	DEG_APCC_DBOX_1	0.5806
p.K411N	DO49964	CESC	ICGC	KRNTLNPVY	DEG_APCC_DBOX_1	0.5806
p.P428S	TCGA-FW-A3R5	SKCM	TCGA	KRNTLNPVY	DEG_APCC_DBOX_1	0.0833
p.P428S	DO37406	SKCM	ICGC	KRNTLNPVY	DEG_APCC_DBOX_1	0.0833
p.E421K	TCGA-IQ-7632	HNSC	TCGA	KRNTLNPVY	DEG_APCC_DBOX_1	0.2778
p.E421K	DO14353	HNSC	ICGC	KRNTLNPVY	DEG_APCC_DBOX_1	0.2778
p.T414N	DO222762	COCA	ICGC	KRNTLNPVY	DEG_APCC_DBOX_1	0.5944
p.V427F	DO228900	LICA	ICGC	KRNTLNPVY	DEG_APCC_DBOX_1	0.1111
p.V424F	DO228985	LICA	ICGC	KRNTLNPVY	DEG_APCC_DBOX_1	0.1944
p.L415F	DO229045	LICA	ICGC	KRNTLNPVY	DEG_APCC_DBOX_1	0.6981
p.N420H	DO218847	SKCA	ICGC	KRNTLNPVY	DEG_APCC_DBOX_1	0.3056
p.R406G	SIDM01282	Colorectal Carcinoma	GDSC	KRNTLNPVY	DEG_APCC_DBOX_1	0.1944
p.Y419D	SIDM01245	T-Lymphoblastic Leukemia	GDSC	KRNTLNPVY	DEG_APCC_DBOX_1	0.6214
p.Y419D	BE-13	haematopoietic_and_lymphoid_tissue	COSMIC	KRNTLNPVY	DEG_APCC_DBOX_1	0.6214
p.T410I	ACH-001611	Brain Cancer	CCLE	KRNTLNPVY	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86SS6	Synaptotagmin-9	DEG_APCC_DBOX_1	411:419	KRNTLNPVY	APC,CDC20,FZR1	0.5519	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons