DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
NBPF11
UniProt ID:
Q86T75
Entrez ID:
200030
Protein name:
Neuroblastoma breakpoint family member 11 (Neuroblastoma breakpoint family member 24)
External links:
UniprotKB
HGNC
RefSeq
COSMIC
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Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
cytoplasm [GO:0005737]...
cytoplasm [GO:0005737]
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Open in full screen with detailed sequence annotations
NBPF11
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.S773T
DO229268
THCA
ICGC
SRELLEVVE
DEG_APCC_DBOX_1
770:778
Mutation altering degron motif
0.7116
p.S764P
DO229250
THCA
ICGC
SRELLEVVE
DEG_APCC_DBOX_1
770:778
Mutation rewiring degron network
0.1667
p.E780D
SIDM01090
Colorectal Carcinoma
GDSC
SRELLEVVE
DEG_APCC_DBOX_1
770:778
Mutation rewiring degron network
0.2778
p.S770R
SIDM00354
Squamous Cell Lung Carcinoma
GDSC
SRELLEVVE
DEG_APCC_DBOX_1
770:778
Mutation altering degron motif
0.6316
p.V777L
SIDM00708
Non-Small Cell Lung Carcinoma
GDSC
SRELLEVVE
DEG_APCC_DBOX_1
770:778
Mutation altering degron motif
0.5654
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for NBPF11 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc