DegronMD

Uniprot ID: Q86T75

Source protein: Neuroblastoma breakpoint family member 11

Source gene: NBPF11

Class: DEG_APCC_DBOX_1

Location: 770:778

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7458

ASA_SCORE: 73.6889

COIL: 0.4064

CONS_SCORE: 0.636

DSS_SCORE: 0.3913

HELIX: 0.5491

FCONS_SCORE: 1.0632

RIG_SCORE: 0.793

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S773T	DO229268	THCA	ICGC	SRELLEVVE	DEG_APCC_DBOX_1	0.7116
p.S764P	DO229250	THCA	ICGC	SRELLEVVE	DEG_APCC_DBOX_1	0.1667
p.E780D	SIDM01090	Colorectal Carcinoma	GDSC	SRELLEVVE	DEG_APCC_DBOX_1	0.2778
p.S770R	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	SRELLEVVE	DEG_APCC_DBOX_1	0.6316
p.V777L	SIDM00708	Non-Small Cell Lung Carcinoma	GDSC	SRELLEVVE	DEG_APCC_DBOX_1	0.5654

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86T75	Neuroblastoma breakpoint family member 11	DEG_APCC_DBOX_1	770:778	SRELLEVVE	APC,CDC20,FZR1	0.7458	More...
Q8N660	Neuroblastoma breakpoint family member 15	DEG_APCC_DBOX_1	499:507	SRELLEVVE	APC,CDC20,FZR1	0.9841	More...
Q3BBV2	Putative neuroblastoma breakpoint family member 8	DEG_APCC_DBOX_1	735:743	SRELLEVVE	APC,CDC20,FZR1	0.9187	More...
Q5TI25	Neuroblastoma breakpoint family member 14	DEG_APCC_DBOX_1	430:438	SRELLEVVE	APC,CDC20,FZR1	0.6661	More...
Q5TI25	Neuroblastoma breakpoint family member 14	DEG_APCC_DBOX_1	749:757	SRELLEVVE	APC,CDC20,FZR1	0.9535	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons