DegronMD

Uniprot ID: Q5TI25

Source protein: Neuroblastoma breakpoint family member 14

Source gene: NBPF14

Class: DEG_APCC_DBOX_1

Location: 749:757

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9535

ASA_SCORE: 85

COIL: 0.4086

CONS_SCORE: 0.6043

DSS_SCORE: 0.5083

HELIX: 0.5666

FCONS_SCORE: 1.1323

RIG_SCORE: 0.7764

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V755A	DO225376	BRCA	ICGC	SRELLEVVE	DEG_APCC_DBOX_1	0.5825
p.V755A	DO229275	THCA	ICGC	SRELLEVVE	DEG_APCC_DBOX_1	0.5825
p.V755A	DO229224	THCA	ICGC	SRELLEVVE	DEG_APCC_DBOX_1	0.5825
p.L753V	DO229253	THCA	ICGC	SRELLEVVE	DEG_APCC_DBOX_1	0.6765
p.G742D	DO229201	THCA	ICGC	SRELLEVVE	DEG_APCC_DBOX_1	0.1389
p.V756A	ACH-000407	Endometrial/Uterine Cancer	CCLE	SRELLEVVE	DEG_APCC_DBOX_1	0.6936
p.V756A	ACH-000513	Kidney Cancer	CCLE	SRELLEVVE	DEG_APCC_DBOX_1	0.6936
p.V756A	ACH-001210	Rhabdoid	CCLE	SRELLEVVE	DEG_APCC_DBOX_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86T75	Neuroblastoma breakpoint family member 11	DEG_APCC_DBOX_1	770:778	SRELLEVVE	APC,CDC20,FZR1	0.7458	More...
Q8N660	Neuroblastoma breakpoint family member 15	DEG_APCC_DBOX_1	499:507	SRELLEVVE	APC,CDC20,FZR1	0.9841	More...
Q3BBV2	Putative neuroblastoma breakpoint family member 8	DEG_APCC_DBOX_1	735:743	SRELLEVVE	APC,CDC20,FZR1	0.9187	More...
Q5TI25	Neuroblastoma breakpoint family member 14	DEG_APCC_DBOX_1	430:438	SRELLEVVE	APC,CDC20,FZR1	0.6661	More...
Q5TI25	Neuroblastoma breakpoint family member 14	DEG_APCC_DBOX_1	749:757	SRELLEVVE	APC,CDC20,FZR1	0.9535	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons