DegronMD

Uniprot ID: Q5TI25

Source protein: Neuroblastoma breakpoint family member 14

Source gene: NBPF14

Class: DEG_APCC_DBOX_1

Location: 430:438

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6661

ASA_SCORE: 91.9444

COIL: 0.6211

CONS_SCORE: 0.6293

DSS_SCORE: 0.5083

HELIX: 0.2699

FCONS_SCORE: 1.0893

RIG_SCORE: 0.7764

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L434V	DO225335	BRCA	ICGC	SRELLEVVE	DEG_APCC_DBOX_1	0.6765
p.L434V	DO229181	THCA	ICGC	SRELLEVVE	DEG_APCC_DBOX_1	0.6765
p.L434V	DO229253	THCA	ICGC	SRELLEVVE	DEG_APCC_DBOX_1	0.6765
p.G423D	DO227486	LAML	ICGC	SRELLEVVE	DEG_APCC_DBOX_1	0.1389
p.G423D	DO224576	LUSC	ICGC	SRELLEVVE	DEG_APCC_DBOX_1	0.1389
p.G423D	DO224589	LUSC	ICGC	SRELLEVVE	DEG_APCC_DBOX_1	0.1389
p.G423D	DO224610	LUSC	ICGC	SRELLEVVE	DEG_APCC_DBOX_1	0.1389
p.G423D	DO229121	THCA	ICGC	SRELLEVVE	DEG_APCC_DBOX_1	0.1389
p.G423D	DO229253	THCA	ICGC	SRELLEVVE	DEG_APCC_DBOX_1	0.1389
p.G423D	DO229227	THCA	ICGC	SRELLEVVE	DEG_APCC_DBOX_1	0.1389
p.G423D	DO229250	THCA	ICGC	SRELLEVVE	DEG_APCC_DBOX_1	0.1389
p.V436A	DO229167	THCA	ICGC	SRELLEVVE	DEG_APCC_DBOX_1	0.5825
p.Q443H	ACH-000869	Lung Cancer	CCLE	SRELLEVVE	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86T75	Neuroblastoma breakpoint family member 11	DEG_APCC_DBOX_1	770:778	SRELLEVVE	APC,CDC20,FZR1	0.7458	More...
Q8N660	Neuroblastoma breakpoint family member 15	DEG_APCC_DBOX_1	499:507	SRELLEVVE	APC,CDC20,FZR1	0.9841	More...
Q3BBV2	Putative neuroblastoma breakpoint family member 8	DEG_APCC_DBOX_1	735:743	SRELLEVVE	APC,CDC20,FZR1	0.9187	More...
Q5TI25	Neuroblastoma breakpoint family member 14	DEG_APCC_DBOX_1	430:438	SRELLEVVE	APC,CDC20,FZR1	0.6661	More...
Q5TI25	Neuroblastoma breakpoint family member 14	DEG_APCC_DBOX_1	749:757	SRELLEVVE	APC,CDC20,FZR1	0.9535	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons