DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
SRELLEVVE
Uniprot ID:
Q3BBV2
Source protein:
Putative neuroblastoma breakpoint family member 8
Source gene:
NBPF8
Class:
DEG_APCC_DBOX_1
Location:
735:743
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9187
ASA_SCORE:
79.5111
COIL:
0.3684
CONS_SCORE:
0.5879
DSS_SCORE:
0.5083
HELIX:
0.6054
FCONS_SCORE:
1.1508
RIG_SCORE:
0.7764
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with NBPF8 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SRELLEVVE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q86T75
Neuroblastoma breakpoint family member 11
DEG_APCC_DBOX_1
770:778
SRELLEVVE
APC,CDC20,FZR1
0.7458
More...
Q8N660
Neuroblastoma breakpoint family member 15
DEG_APCC_DBOX_1
499:507
SRELLEVVE
APC,CDC20,FZR1
0.9841
More...
Q3BBV2
Putative neuroblastoma breakpoint family member 8
DEG_APCC_DBOX_1
735:743
SRELLEVVE
APC,CDC20,FZR1
0.9187
More...
Q5TI25
Neuroblastoma breakpoint family member 14
DEG_APCC_DBOX_1
430:438
SRELLEVVE
APC,CDC20,FZR1
0.6661
More...
Q5TI25
Neuroblastoma breakpoint family member 14
DEG_APCC_DBOX_1
749:757
SRELLEVVE
APC,CDC20,FZR1
0.9535
More...